Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2709 |
| PDBID: | 6PHD |
| Chains: | HL_C |
| Organism: | Homo sapiens, Plasmodium falciparum |
| Method: | XRD |
| Resolution (Å): | 3.10 |
| Reference: | 10.1038/s41467-019-11980-6 |
| Antibody | |
| Antibody: | 2586 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | 25 kDa ookinete surface antigen (Pfs25) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6PHD_H|Chain A[auth H]|2586 Antibody Fab, Heavy Chain|Homo sapiens (9606) EVHLVESGGGLVQPGGSLRLSCAASGFTFSDHYMDWVRQAPGKGLEWVGRIRNKANSYTTDYAASVKGRFTILRDDSKNSLYLQMNSLKTEDAAVYYCVRVGGLGERGDYYYYYMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: L
Mutation: NULL
| >6PHD_L|Chain B[auth L]|2586 Antibody Fab, Light Chain|Homo sapiens (9606) SYELTQPPSVSFSPGQTARITCSGDALSKQYTYWYQQKPGQAPVLVIYKDSERPSGIPERFSGSSSGTTVTLTISGVQAEDEADYYCQSADSSGPYQVLFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: C
Mutation: NULL
| >6PHD_C|Chain C|25 kDa ookinete surface antigen|Plasmodium falciparum (5833) ETGAKVTVDTVCKRGFLIQMSGHLECKCENDLVLVNEETCEEKVLKCDEKTVNKPCGDFSKCIKIDGNPVSYACKCNLGYDMVNNVCIPNECKQVTCGNGKCILDTSNPVKTGVCSCNIGKVPNVQDQNKCSKDGETKCSLKCLKEQETCKAVDGIYKCDCKDGFIIDQESSICTGTKHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: TYR33 ARG52 ASN56 GLU106 ARG107 ASP109 TYR110 TYR111 TYR112 TYR113 L: LEU28 SER29 LYS30 GLN31 TYR32 TYR34 ASP51 GLU53 SER66 ALA91 SER93 SER94 GLY95 PRO96 TYR97 C: ASN96 ASN115 ILE116 GLY117 LYS118 VAL119 VAL122 LYS130 ASP131 GLY132 GLU133 THR134 LYS135 CYS136 THR146 CYS147 LYS148 ALA149 ASP151 GLY152 TYR154 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
