Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2707 |
| PDBID: | 6PHC |
| Chains: | AB_I |
| Organism: | Plasmodium falciparum, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.90 |
| Reference: | 10.1038/s41467-019-11980-6 |
| Antibody | |
| Antibody: | 2544 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | 25 kDa ookinete surface antigen (Pfs25) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >6PHC_A|Chain B[auth A], E[auth C]|2544 Antibody Fab, Heavy Chain|Homo sapiens (9606) EVQLVESGGGLVQPGGSLRLSCVASGFTFSNYNMNWVRQAPGKGLEWLSYISSSSGTIYYADSVKGRFTISRDNAKNSMYLQMNSLRAEDTAVYYCVRVEYYYGSSGYYYDFDSWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: B
Mutation: NULL
| >6PHC_B|Chain C[auth B], F[auth D]|2544 Antibody Fab, Light Chain|Homo sapiens (9606) DIVMTQSPLSLPVTPGEPASISCRSSQSLLHNGYNYLDWYLQKPGQSPQLLIYLGSNRASGVPDRFSGSGSGTDFTLKISRVEAEDVGVYYCMQTLQPFTFGQGTRLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: I
Mutation: NULL
| >6PHC_I|Chain A[auth E], D[auth I]|25 kDa ookinete surface antigen|Plasmodium falciparum (5833) ETGAKVTVDTVCKRGFLIQMSGHLECKCENDLVLVNEETCEEKVLKCDEKTVNKPCGDFSKCIKIDGNPVSYACKCNLGYDMVNNVCIPNECKQVTCGNGKCILDTSNPVKTGVCSCNIGKVPNVQDQNKCSKDGETKCSLKCLKEQETCKAVDGIYKCDCKDGFIIDQESSICTGTKHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition A: SER30 ASN31 TYR32 ASN33 TYR50 SER52 SER53 GLY55 THR56 TYR58 GLU96 TYR97 TYR98 TYR99 B: HIS27 ASN28 GLY29 TYR30 TYR32 THR91 LEU92 PRO94 I: ALA1 LYS2 VAL3 THR4 VAL5 ASP6 THR7 VAL8 GLN16 SER18 GLY19 HIS20 LEU21 ASN33 GLU34 GLU35 THR36 ILE100 ASP102 THR103 SER104 LYS135 CYS136 SER137 LEU138 LYS139 CYS140 LEU141 CYS147 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
