Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2705 |
| PDBID: | 6PHB |
| Chains: | DC_I |
| Organism: | Plasmodium falciparum, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.00 |
| Reference: | 10.1038/s41467-019-11980-6 |
| Antibody | |
| Antibody: | 2530 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | 25 kDa ookinete surface antigen (Pfs25) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >6PHB_D|Chain C[auth B], F[auth D]|2530 Antibody Fab, Heavy Chain|Homo sapiens (9606) QVQLQESGPGLVKPSETLSLTCTVSGDSMSSYYWSWIRQPAGKGLEWIGRISTSGSTNYNPSLKSRVTMSVDTSNNHFSMRLNSVTAADTAVYYCACSGSYSFFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: C
Mutation: NULL
| >6PHB_C|Chain B[auth A], E[auth C]|2530 Antibody Fab, Light Chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCQASQDISNFLNWYQQKPGKAPKLLIYDASNLETGVPSRFSGSGSGTDFTFTISSLQPEDIATYYCQQYDNLRIFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: I
Mutation: NULL
| >6PHB_I|Chain A[auth E], D[auth I]|25 kDa ookinete surface antigen|Plasmodium falciparum (5833) ETGAKVTVDTVCKRGFLIQMSGHLECKCENDLVLVNEETCEEKVLKCDEKTVNKPCGDFSKCIKIDGNPVSYACKCNLGYDMVNNVCIPNECKQVTCGNGKCILDTSNPVKTGVCSCNIGKVPNVQDQNKCSKDGETKCSLKCLKEQETCKAVDGIYKCDCKDGFIIDQESSICTGTKHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition C: PHE32 TYR49 ASP50 GLU55 THR56 TYR91 ASN93 ARG95 D: GLN1 ASP27 SER30 SER31 TYR32 TYR33 ARG50 SER52 SER54 SER56 GLY99 SER100 TYR101 PHE103 ASP105 TYR106 I: ARG11 ASN27 ASP28 LEU29 GLU38 GLU39 LYS40 VAL41 LEU42 LYS43 ASP45 GLU46 LYS47 THR48 LYS51 PRO52 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
