Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 27 |
| PDBID: | 1E6J |
| Chains: | HL_P |
| Organism: | Mus musculus, HIV-1 M |
| Method: | XRD |
| Resolution (Å): | 3.00 |
| Reference: | 10.1016/s0969-2126(00)00507-4 |
| Antibody | |
| Antibody: | 13B5 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 capsid protein (p24) |
| Antigen mutation: | No |
| Durg Target: | Q72497; P03367; P04587; P03366; P04585; P03369; P35963; O93182; P12497; P12499; |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >1E6J_H|Chain A[auth H]|IMMUNOGLOBULIN|MUS MUSCULUS (10090) EVQLQQSGAELARPGASVKMSCKASGYTFTSYTMHWVKQRPGQGLEWIGYINPSSGYSNYNQKFKDKATLTADKSSSTAYMQLSSLTSEDSAVYYCSRPVVRLGYNFDYWGQGSTLTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVP |
Light Chain: L
Mutation: NULL
| >1E6J_L|Chain B[auth L]|IMMUNOGLOBULIN|MUS MUSCULUS (10090) EIVLTQSPAITAASLGQKVTITCSASSSVSYMHWYQQKSGTSPKPWIYEISKLASGVPARFSGSGSGTSYSLTISSMEAEDAAIYYCQQWNYPFTFGSGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRN |
Antigen
Chain: P
Mutation: NULL
| >1E6J_P|Chain C[auth P]|CAPSID PROTEIN P24|HIV-1 M\:B_HXB2R (11706) VHQAISPRTLNAWVKVVEEKAFSPEVIPMFSALSEGATPQDLNTMLNTVGGHQAAMQMLKETINEEAAEWDRVHPVHAGPIAPGQMREPRGSDIAGTTSTLQEQIGWMTNNPPIPVGEIYKRWIILGLNKIVRMYSPTSILDIRQGPKEPFRDYVDRFYKTLRAEQASQEVKNWMTETLLVQNANPDCKTILKALGPAATLEEMMTACQG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: THR30 SER31 TYR32 THR33 TYR50 ILE51 ASN52 SER54 SER55 TYR57 ASN59 VAL101 ARG102 LEU103 GLY104 TYR105 L: TRP90 ASN91 TYR92 PHE94 P: GLU187 THR200 ILE201 LYS203 ALA204 LEU205 GLY206 PRO207 ALA208 ALA209 THR210 GLU212 GLU213 THR216 ALA217 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
