Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2698 |
| PDBID: | 6PDX |
| Chains: | MN_B |
| Organism: | Influenza A virus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.99 |
| Reference: | 10.1128/JVI.01035-19 |
| Antibody | |
| Antibody: | C585 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H3N2 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: M
Mutation: NULL
| >6PDX_M|Chain B[auth H], E[auth M], H[auth O]|C585 Fab heavy chain|Homo sapiens (9606) QVQLQESGPGLVKPSETLSLTCAVSGASISSFYWSWIRQSPGKGLEWIAYIYYSGKTQYNPAVTGRATISLQNWNNHVALRVNSVTAADTAIYSCARHTLAYHYDDEGYMQPGDAFDLWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHT |
Light Chain: N
Mutation: NULL
| >6PDX_N|Chain C[auth L], F[auth N], I[auth P]|C585 Fab light chain|Homo sapiens (9606) QSVLTQPPSVSAPAGQMVTIPCSGSSSDIGKSFVSWYQQLPGTAPKLVIYDNNKRPSGIPDRFSGSKSGTSATLGITGLQTGDEAVYYCGTWDSSLIWVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: B
Mutation: NULL
| >6PDX_B|Chain A, D[auth B], G[auth C]|Hemagglutinin|Influenza A virus (11320) QKLPGNDNSTATLCLGHHAVPNGTIVKTITNDRIEVTNATELVQNSSIGEICDSPHQILDGENCTLIDALLGDPQCDGFQNKKWDLFVERSKAYSNCYPYDVPDYASLRSLVASSGTLEFNNESFNWAGVTQNGTSSSCRRGSNSSFFSRLNWLTHLNSKYPALNVTMPNNEQFDKLYIWGVHHPVTDKDQIFLYAQSSGRITVSTKRSQQAVIPNIGSRPRIRDIPSRISIYWTIVKPGDILLINSTGNLIAPRGYFKIRSGKSSIMRSDAPIGKCKSECITPNGSIPNDKPFQNVNRITYGACPRYVKQSTLKLATGMRNVPERQTRGIFGAIAGFIENGWEGMVDGWYGFRHQNSEGRGQAADLKSTQAAIDQINGKLNRLIGKTNEKFHQIEKEFSEVEGRIQDLEKYVEDTKIDLWSYNAELLVALENQHTIDLTDSEMNKLFEKTKKQLRENAEDMGNGCFKIYHKCDNACIGSIRNGTYDHDVYRDEALNNRFQIKGS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| M: GLY26 ALA27 SER28 ILE29 SER30 SER31 PHE32 TYR52 TYR53 SER54 ASN73 ASN76 LEU100 TYR102 TYR104 ASP105 ASP106 GLU107 GLY108 TYR109 MET110 B: GLU119 ASN121 ASN122 GLU123 SER124 PHE125 ASN126 THR167 MET168 PRO169 ASN171 GLU172 GLN173 PHE174 LYS176 GLY240 TYR257 ARG261 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
