Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2688 |
| PDBID: | 6P9H |
| Chains: | HL_A |
| Organism: | Staphylococcus aureus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.00 |
| Reference: | 10.1128/mBio.02473-19 |
| Antibody | |
| Antibody: | STAU-281 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Iron-regulated heme-iron binding protein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6P9H_H|Chain B[auth C], E[auth H]|Human anti staphylococcus aureus antibody STAU-281 Fab heavy chain|Homo sapiens (9606) QVQLVQSGAEVKRPGSSVRVSCKDSGDSFRRYVINWVRQAPGQGLEWMGGIIPIFDKAKSVQKFQDRLTITADESTSTSYMELSSLTSEDTAVYYCARKEDGRRDDVFDIWGQGTLVTVSSASFKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPK |
Light Chain: L
Mutation: NULL
| >6P9H_L|Chain C[auth D], F[auth L]|Human anti staphylococcus aureus antibody STAU-281 Fab light chain|Homo sapiens (9606) EIVMTQSPATLSVSLGERATLSCRASHSVGSSLAWYQQKPGLAPRLLIYGVSTRATGIPARFSGSGSATEFTLTISSLQSEDLAAYHCQQYDNWPFTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGE |
Antigen
Chain: A
Mutation: NULL
| >6P9H_A|Chain A, D[auth B]|Iron-regulated heme-iron binding protein|Staphylococcus aureus (1280) MKMTDLQDTKYVVYESVENNESMMDTFVKHPIKTGMLNGKKYMVMETTNDDYWKDFMVEGQRVRTISKDAKNNTRTIIFPYVEGKTLYDAIVKVHVKTIDYDGQYHVRIVDKEAFTKA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ARG30 ARG31 TYR32 VAL33 ASN35 TRP47 GLY50 ILE52 ILE54 PHE55 LYS57 ALA58 LYS59 LYS99 GLY102 ARG103 ARG104 ASP106 PHE108 L: TYR91 ASP92 TRP94 PHE96 A: MET362 MET363 THR365 PHE366 THR387 ASN388 ASP389 ASP390 TYR391 TRP392 ALA409 LYS410 ASN411 ASN412 ARG414 VAL433 VAL435 LYS436 THR437 ILE438 ASP439 TYR440 TYR444 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
