Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 267 |
| PDBID: | 2HFG |
| Chains: | HL_R |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.61 |
| Reference: | 10.1182/blood-2006-03-011031 |
| Antibody | |
| Antibody: | CB3s Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Tumor necrosis factor receptor superfamily member 13C (BAFF-R) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >2HFG_H|Chain B[auth H]|CB3s Fab heavy chain|Homo sapiens (9606) EVQLVESGGGLVQPGGSLRLSCAASGFTISSSSIHWVRQAPGKGLEWVAWVLPSVGFTDYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARRVCYNRLGVCAGGMDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTH |
Light Chain: L
Mutation: NULL
| >2HFG_L|Chain A[auth L]|CB3s Fab light chain (kappa)|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCRASQDVSTAVAWYQQKPGKAPKLLIYSASFLYSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSQISPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: R
Mutation: NULL
| >2HFG_R|Chain C[auth R]|Tumor necrosis factor receptor superfamily member 13C|Homo sapiens (9606) GSYSLRGRDAPAPTPCNPAECFDPLVRHCVACGLLRTPRPKPAGASSPAPR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: TYR49 PHE53 LEU54 SER91 GLN92 SER94 PRO96 H: SER31 SER32 SER33 HIS35 TRP50 SER53 VAL54 PHE56 ARG95 CYS97 TYR98 ASN99 R: GLU23 CYS24 PHE25 ASP26 PRO27 LEU28 VAL29 ARG30 HIS31 CYS32 VAL33 ALA34 CYS35 GLY36 LEU37 LEU38 ARG39 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
