Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2657 |
| PDBID: | 6OY4 |
| Chains: | DC_A |
| Organism: | Dermatophagoides pteronyssinus, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.45 |
| Reference: | 10.4049/jimmunol.1900580 |
| Antibody | |
| Antibody: | 7A1 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Dermatophagoides pteronyssinus 2 variant 3 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >6OY4_D|Chain C[auth D]|Fab fragment of IgG, HEAVY CHAIN|Mus musculus (10090) QIQLVQSGPELKKPGETIKISCKASGYTFTNYGMNWVKQTPGKGLKWMGWINPYTGEEPSYADDFKGRFAFSLETSANTAYLQINNLNNEDMATYFCARGGFTDYYGMDYWGQGTSVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSASSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPR |
Light Chain: C
Mutation: NULL
| >6OY4_C|Chain B[auth C]|Fab fragment of IgG, LIGHT CHAIN|Mus musculus (10090) DIVLTQSPASLAVSLGQRATISCKASQSVDYGGNSYVNWYQQKPGQPPKLLIYAASNLKSGIPARFSGSGSGTDFTLNIHPVEEEDAATYYCQQSNEDPWTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVAWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRN |
Antigen
Chain: A
Mutation: NULL
| >6OY4_A|Chain A|Der p 2 variant 3|Dermatophagoides pteronyssinus (6956) DQVDVKDCANHEIKKVLVPGCHGSEPCIIHRGKPFQLEALFEANQNSKTAKIEIKASIDGLEVDVPGIDPNACHYMKCPLVKGQQYDIKYTWNVPKIAPKSENVVVTVKVMGDNGVLACAIATHAKIRD |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: TYR31 GLY32 GLY33 ASN34 TYR36 SER95 ASN96 ASP98 TRP100 D: ASN31 TYR32 GLY33 TRP50 ASN52 TYR54 THR55 GLU57 SER60 GLY100 GLY101 PHE102 THR103 ASP104 A: PRO19 ILE28 HIS30 ARG31 GLY32 LYS33 PRO34 PHE35 GLN36 PRO66 ASN93 VAL94 PRO95 LYS96 ILE97 PRO99 LYS100 ASP129 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
