Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2648 |
| PDBID: | 6OSH |
| Chains: | HL_K |
| Organism: | Oryctolagus cuniculus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.12 |
| Reference: | 10.1074/jbc.RA120.012791 |
| Antibody | |
| Antibody: | 401 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Tyrosine-protein kinase transmembrane receptor ROR2 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6OSH_H|Chain C[auth H]|Antibody heavy chain variable region|Oryctolagus cuniculus (9986) MQSVKESEGGLFKPTDTLTLTCTVSGFSLSSYGVTWVRQAPGSGLEWIGYINTAGNTYYASWAKSRSTITRNTNENTVTLKMTSLTAADTATYFCARDWTSLNIWGPGTLVTVS |
Light Chain: L
Mutation: NULL
| >6OSH_L|Chain A[auth L]|Antibody Light chain variable region|Oryctolagus cuniculus (9986) GGSDPMLTQTPSSTSTAVGDTVTIKCQASQSISSDLSWYQQKPGQRPKLLIYQASTLASGVPSRFKGSGYGTEYTLTISGVQREDAAIYYCLGGYADASYRTAFGGGTKLEIK |
Antigen
Chain: K
Mutation: NULL
| >6OSH_K|Chain B[auth K]|Tyrosine-protein kinase transmembrane receptor ROR2|Homo sapiens (9606) MGSHHHHHHLVPRGSHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSC |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: ILE29 SER30 SER31 ASP32 GLN50 TYR67 TYR71 GLY90 GLY91 TYR92 ALA93 ASP94 ALA95 SER96 TYR97 ARG98 THR99 H: TYR49 ASN51 THR52 ALA53 GLY54 ASN55 TYR57 TRP98 THR99 K: GLN343 HIS344 PRO345 HIS346 SER347 HIS348 HIS349 LEU350 SER351 THR353 ASP354 PHE355 PRO368 GLY369 GLN371 TRP376 PHE378 LYS382 ARG385 MET386 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
