Complex | |
AACDB_ID: | 2634 |
PDBID: | 6ORN |
Chains: | FI_K |
Organism: | Human immunodeficiency virus 1, Homo sapiens |
Method: | EM |
Resolution (Å): | 4.05 |
Reference: | 10.1038/s41586-019-1250-z |
Antibody | |
Antibody: | 10-1074 Fab |
Antibody mutation: | No |
INN (Clinical Trial): | Zinlirvimab(Phase-II) |
Antigen | |
Antigen: | HIV-1 BG505 SOSIP-based immunogen RC1 gp120 |
Antigen mutation: | No |
Durg Target: |
Antibody
Heavy Chain: F
Mutation: NULL
>6ORN_F|Chain G[auth A], H[auth F], I[auth O]|10-1074 antibody Fab heavy chain|Homo sapiens (9606) QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKT |
Light Chain: I
Mutation: NULL
>6ORN_I|Chain J[auth B], K[auth I], L[auth P]|10-1074 antibody Fab light chain|Homo sapiens (9606) SYVRPLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: K
Mutation: NULL
>6ORN_K|Chain B[auth G], D[auth K], F[auth R]|RC1 variant of HIV-1 Env glycoprotein gp120|Human immunodeficiency virus 1 (11676) AENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHEDIISLWDQSLKPCVKLTPLCVTLQCTNYAPNLLSNMRGELKQCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVIIRSENITNNAKNILVQLNTPVQINCTRPNNNTVKSIRIGPGQAFYYFGDIIGDIRMAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFAQSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSIVLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVGRRRRRR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
I: LEU28 GLY29 SER30 PHE67 SER93 ARG94 K: TYR134 ALA135 PRO136 ASN137 LEU138 LEU139 SER140 ASN149 ILE322 ILE323 GLY324 ASP325 ILE326 ARG327 MET328 HIS330 VAL415 PRO417 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)