Details

Structure visualisation

Display styles :





Display color :





Entry information

Complex
AACDB_ID: 2634
PDBID: 6ORN
Chains: FI_K
Organism: Human immunodeficiency virus 1, Homo sapiens
Method: EM
Resolution (Å): 4.05
Reference: 10.1038/s41586-019-1250-z
Antibody
Antibody: 10-1074 Fab
Antibody mutation: No
INN (Clinical Trial): Zinlirvimab(Phase-II)
Antigen
Antigen: HIV-1 BG505 SOSIP-based immunogen RC1 gp120
Antigen mutation: No
Durg Target:

Sequence information

Antibody

Heavy Chain: F
Mutation: NULL

>6ORN_F|Chain G[auth A], H[auth F], I[auth O]|10-1074 antibody Fab heavy chain|Homo sapiens (9606)
QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQSPGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSLKLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKT

Light Chain: I
Mutation: NULL

>6ORN_I|Chain J[auth B], K[auth I], L[auth P]|10-1074 antibody Fab light chain|Homo sapiens (9606)
SYVRPLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILLIYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEADYYCHMWDSRSGFSWSFGGATRLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS

Antigen

Chain: K
Mutation: NULL

>6ORN_K|Chain B[auth G], D[auth K], F[auth R]|RC1 variant of HIV-1 Env glycoprotein gp120|Human immunodeficiency virus 1 (11676)
AENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHEDIISLWDQSLKPCVKLTPLCVTLQCTNYAPNLLSNMRGELKQCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVIIRSENITNNAKNILVQLNTPVQINCTRPNNNTVKSIRIGPGQAFYYFGDIIGDIRMAHCNVSKATWNETLGKVVKQLRKHFGNNTIIRFAQSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSIVLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVGRRRRRR

Interaction

1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.

Interacting residues (ΔSASA based)

I: LEU28 GLY29 SER30 PHE67 SER93 ARG94

K: TYR134 ALA135 PRO136 ASN137 LEU138 LEU139 SER140 ASN149 ILE322 ILE323 GLY324 ASP325 ILE326 ARG327 MET328 HIS330 VAL415 PRO417

2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.

Interacting residues (Atom distance based)

Download

Download sequences
Download structure
Download interacting residues (ΔSASA based)
Download interacting residues (Distance based)