Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2609 |
| PDBID: | 6OL7 |
| Chains: | KJ_F |
| Organism: | Mus musculus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.42 |
| Reference: | 10.1084/jem.20190446 |
| Antibody | |
| Antibody: | anti-idiotype iv8 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | glVRC01 Fv light chain |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: K
Mutation: NULL
| >6OL7_K|Chain A, E, J[auth K], O[auth P]|iv8 Heavy Chain|Mus musculus (10090) GGSEVKLVESGGDFVKPGGSLKLSCAASGFTFSNSAMSWVRQTPEKRLEWVATINNNGGYTHYPDTLKDRFTISRDNVKNTLYLQMSSLRSEDTALYYCTRQTYWYLDVWGAGTTVTVSSGSGSGHHHHHH |
Light Chain: J
Mutation: NULL
| >6OL7_J|Chain D, I[auth J], N[auth O], P[auth Q]|iv8 Light Chain|Mus musculus (10090) DVVMSQSPSSLTVSLGEKVTMTCKSSQSLLYSGNQKNYLAWYQQKPGQSPKLLIYWASTRESGVPDRFTGSGSGTDFTLIISSVKAEDLAVYYCQQFYFYPWTFGGGTKLEIKGGGGSGGGGSGG |
Antigen
Chain: F
Mutation: NULL
| >6OL7_F|Chain B, F, K[auth L], M[auth N]|glVRC01 Light Chain|Homo sapiens (9606) EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQYEFFGQGTKLEIGGGGSGGGG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| J: GLY27 ASN28 TYR32 PHE91 TYR92 PHE93 TYR94 TRP96 K: ALA33 ASN52 ASN53 GLY55 TYR56 THR57 HIS58 TYR59 LYS64 TYR97 TRP98 F: ILE2 GLN27 SER28 VAL29 SER30 SER31 TYR32 ASP50 ALA51 SER52 ASN53 SER65 GLY66 SER67 GLY68 THR69 PHE71 TYR91 GLU96 PHE97 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
