Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2608 |
| PDBID: | 6OL7 |
| Chains: | KJ_I |
| Organism: | Mus musculus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.42 |
| Reference: | 10.1084/jem.20190446 |
| Antibody | |
| Antibody: | anti-idiotype iv8 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | glVRC01 Fv heavy chain |
| Antigen mutation: | No |
| Durg Target: | P23083 |
Sequence information
Antibody
Heavy Chain: K
Mutation: NULL
| >6OL7_K|Chain A, E, J[auth K], O[auth P]|iv8 Heavy Chain|Mus musculus (10090) GGSEVKLVESGGDFVKPGGSLKLSCAASGFTFSNSAMSWVRQTPEKRLEWVATINNNGGYTHYPDTLKDRFTISRDNVKNTLYLQMSSLRSEDTALYYCTRQTYWYLDVWGAGTTVTVSSGSGSGHHHHHH |
Light Chain: J
Mutation: NULL
| >6OL7_J|Chain D, I[auth J], N[auth O], P[auth Q]|iv8 Light Chain|Mus musculus (10090) DVVMSQSPSSLTVSLGEKVTMTCKSSQSLLYSGNQKNYLAWYQQKPGQSPKLLIYWASTRESGVPDRFTGSGSGTDFTLIISSVKAEDLAVYYCQQFYFYPWTFGGGTKLEIKGGGGSGGGGSGG |
Antigen
Chain: I
Mutation: NULL
| >6OL7_I|Chain C, G[auth H], H[auth I], L[auth M]|glVRC01 Heavy Chain|Homo sapiens (9606) SGGGGSQVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYMHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQGRVTMTRDTSISTAYMELSRLRSDDTAVYYCARGKNSDYNWDFQHWGQGTLVTVGGLVPRGSHHHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| J: GLY27 ASN28 GLN29 K: TYR97 TRP98 I: TRP47 TRP50 ASN58 ASP99 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
