Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2605 |
| PDBID: | 6OL6 |
| Chains: | AB_H |
| Organism: | Mus musculus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.60 |
| Reference: | 10.1084/jem.20190164 |
| Antibody | |
| Antibody: | anti-idiotype ib2 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | iglb12 Fv heavy chain |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >6OL6_A|Chain A|ib2 Heavy Chain|Mus musculus (10090) QVQLQQSGAELARPGASVKLSCKASGYTFTSYGITWVKQRTGQGLEWIGEIYPRSGKNWYNERFKGKATLTADTSSSTAYMEFRSLTSEDSAVYFCARTEYGSSPQWYFDAWGTGTTVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKIVPRDCGCK |
Light Chain: B
Mutation: NULL
| >6OL6_B|Chain B|ib2 Light Chain|Mus musculus (10090) SIVMTQTPKFLPVTADDRVTITCKASQILNNEVAWYQQKPGQSPKLLIFYASNRYTGVPDRFTGSGSGTDFTFTISSVQVEDLAVYFCQQHYSSPYTFGGGTKLEVKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: H
Mutation: NULL
| >6OL6_H|Chain C[auth H]|iglb12 Heavy Chain|Homo sapiens (9606) GSQVQLVQSGAEVKKPGASVKVSCKASGYTFTSYAMHWVRQAPGQRLEWMGWINAGNGNTKYSQKFQGRVTITRDTSASTAYMELSSLRSEDTAVYYCARVGPYCGGDSPQDNYYMDVWGKGTTVTVSSSAWSHPQFEK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: ARG53 SER54 LYS56 TRP58 GLU96 TYR97 GLY98 SER99 B: ASN30 ASN31 GLU32 PHE49 TYR50 SER52 ASN53 H: THR28 THR30 SER31 TYR32 ALA33 GLY53 ASN54 ASN56 ARG71 THR73 SER74 VAL95 PRO97 TYR98 CYS99 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
