Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2604 |
| PDBID: | 6OL5 |
| Chains: | AB_L |
| Organism: | Mus musculus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.90 |
| Reference: | 10.1084/jem.20190164 |
| Antibody | |
| Antibody: | anti-idiotype ib3 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | iglb12 Fab light chain |
| Antigen mutation: | No |
| Durg Target: | P01834 |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >6OL5_A|Chain A|ib3 Heavy Chain|Mus musculus (10090) QVQLQQSGPELVKPGASVKMSCKASGYTFTDYYMHWVKQSHGKSLEWIGYFYPNNGGDGYNQKFKGKATLTIDKSSSTAYMELRSLTSEDSAVYYCARGGDWYFDVWGAGTTVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLESDLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKIVPRDCGCK |
Light Chain: B
Mutation: NULL
| >6OL5_B|Chain B|ib3 Light Chain|Mus musculus (10090) ETTVTQSPASLSMAIGEKVTIRCITSTDIDDDMNWYQQKPGEPPKLLISEGNTLRPGVPSRFSSSGFDTDFVFTIENMLSEDAADYYCLQSDNSPFTFGGGTKLQIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: L
Mutation: NULL
| >6OL5_L|Chain D[auth L]|iglb12 Light Chain|Homo sapiens (9606) EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQYGSSSYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: TRP98 B: SER26 THR27 ASP28 ASP30 ASP32 ASP68 THR69 ASP92 ASN93 SER94 L: GLU1 ILE2 SER29 GLY92 SER93 SER94 SER95 TYR96 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
