Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2603 |
| PDBID: | 6OL5 |
| Chains: | AB_H |
| Organism: | Mus musculus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.90 |
| Reference: | 10.1084/jem.20190164 |
| Antibody | |
| Antibody: | anti-idiotype ib3 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | iglb12 Fab heavy chain |
| Antigen mutation: | No |
| Durg Target: | Q6PYX1; P01857; P01859; P01860; P01861; |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >6OL5_A|Chain A|ib3 Heavy Chain|Mus musculus (10090) QVQLQQSGPELVKPGASVKMSCKASGYTFTDYYMHWVKQSHGKSLEWIGYFYPNNGGDGYNQKFKGKATLTIDKSSSTAYMELRSLTSEDSAVYYCARGGDWYFDVWGAGTTVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLESDLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKIVPRDCGCK |
Light Chain: B
Mutation: NULL
| >6OL5_B|Chain B|ib3 Light Chain|Mus musculus (10090) ETTVTQSPASLSMAIGEKVTIRCITSTDIDDDMNWYQQKPGEPPKLLISEGNTLRPGVPSRFSSSGFDTDFVFTIENMLSEDAADYYCLQSDNSPFTFGGGTKLQIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: H
Mutation: NULL
| >6OL5_H|Chain C[auth H]|iglb12 Heavy Chain|Homo sapiens (9606) QVQLVQSGAEVKKPGASVKVSCKASGYTFTSYAMHWVRQAPGQRLEWMGWINAGNGNTKYSQKFQGRVTITRDTSASTAYMELSSLRSEDTAVYYCARVGPYCGGDSPQDNYYMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: ASP31 TYR32 TYR33 TRP47 TYR50 ASN53 ASN54 GLY56 ASP57 GLY58 TYR59 GLN61 LYS64 GLY96 ASP97 TRP98 TYR99 B: ASP30 ASP31 ASP32 GLU50 GLY51 THR53 PHE67 SER91 ASP92 ASN93 SER94 PHE96 H: THR30 SER31 TRP47 TRP50 GLY53 ASN54 ASN56 THR57 LYS58 TYR59 SER60 GLN61 GLN64 TYR98 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
