Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 26 |
| PDBID: | 1DZB |
| Chains: | B_Y |
| Organism: | Mus musculus, Meleagris gallopavo |
| Method: | XRD |
| Resolution (Å): | 2.00 |
| Reference: | 10.1006/jmbi.2000.3971 |
| Antibody | |
| Antibody: | 1F9 scFv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Turkey Egg White Lysozyme |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: B
Mutation: NULL
| >1DZB_B|Chain A, B|SCFV FRAGMENT 1F9|MUS MUSCULUS (10090) QVKLQQSGAELVKPGASVKLSCTASGFNIKDTYMHWVKQRPEQGLEWIGRIDPANGNTKYDPKFQGKATITADTSSNTAYLQLSSLTSEDTAVYYCARWDWYFDVWGQGTTVTVSSGGGGSGGGGSGGGGSDIELTQSPSSMYTSLGERVTITCKASQDINSYLRWFQQKPGKSPKTLIYYATSLADGVPSRFSGSGSGQDYSLTISSLESDDTTTYYCLQHGESPYTFGGGTKLEIKRAAAEQKLISEEDLN |
Antigen
Chain: Y
Mutation: NULL
| >1DZB_Y|Chain C[auth X], D[auth Y]|TURKEY EGG-WHITE LYSOZYME C|MELEAGRIS GALLOPAVO (9103) KVYGRCELAAAMKRLGLDNYRGYSLGNWVCAAKFESNFNTHATNRNTDGSTDYGILQINSRWWCNDGRTPGSKNLCNIPCSALLSSDITASVNCAKKIASGGNGMNAWVAWRNRCKGTDVHAWIRGCRL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: LYS30 ASP31 THR32 TYR33 HIS35 ARG50 ASP52 ALA54 ASN55 ARG98 TRP99 ASP100 TRP101 TYR102 PHE103 ILE229 ASN230 TYR232 ARG234 TYR250 SER253 LEU254 ASP256 HIS291 GLY292 GLU293 TYR296 Y: TYR20 ARG21 TYR23 ARG61 TRP62 TRP63 LYS73 LEU75 LYS96 LYS97 ILE98 SER100 GLY101 GLY102 ASN103 GLY104 ASN106 ALA107 ARG112 LYS116 GLY117 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
