Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2598 |
| PDBID: | 6OHG |
| Chains: | CB_A |
| Organism: | Plasmodium falciparum, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.38 |
| Reference: | 10.1038/s42003-020-01123-9 |
| Antibody | |
| Antibody: | 4F12 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Plasmodium falciparum vaccine candidateGametocyte surface protein P230 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >6OHG_C|Chain C|4F12 Heavy chain|Mus musculus (10090) QVQLQQPGAELVKPGASVQLSCKASGYTFTSYWMHWVKQRPGQGLEWIGMIHPTNDKTNFNEKLKSKVTLTVDKSSTTAYMQLSSLTSEDAAVYYCARSLSAYWYFDVWGTGTTVTVSSASTKPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCGLEVLFQ |
Light Chain: B
Mutation: NULL
| >6OHG_B|Chain B|4F12 Light Chain|Mus musculus (10090) DILLTQSPAILSVSPGERVSFSCRASQSIGTSIHWYQQKTQGSPRLLIKYSSESISGIPSRFSGSGAGTDFTLSINSVESEDIAVFYCQQSYTWPIFTFGSGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: A
Mutation: NULL
| >6OHG_A|Chain A|Gametocyte surface protein P230|Plasmodium falciparum (5833) SVLQSGALPSVGVDELDKIDLSYETTESGDTAVSEDSYDKYASQNTNKEYVCDFTDQLKPTESGPKVKKCEVKVNEPLIKVKIICPLKGSVEKLYDNIEYVPKKSPYVVLTKEETKLKEKLLSKLIYGLLISPTVNEKENNFKEGVIEFTLPPVVHKATVFYFICDNSKTEDDNKKGNRGIVEVYVEPYGNKING |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: ILE2 GLN27 SER28 ILE29 GLY30 THR31 SER32 LYS49 TYR50 SER52 GLU53 SER54 ALA67 GLY68 SER91 TYR92 TRP94 C: SER101 ALA102 TYR103 TRP104 A: ASP580 LYS581 TYR582 ALA583 SER584 GLN585 ASN586 THR587 VAL592 ASP594 THR596 ASP597 GLN598 LYS600 PRO601 THR602 GLU603 SER604 LYS607 LYS609 VAL632 GLU633 LEU635 ASP713 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
