Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2590 |
| PDBID: | 6OE5 |
| Chains: | HL_A |
| Organism: | Human respiratory syncytial virus A2, Tequatrovirus T4, Mus musculus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 4.10 |
| Reference: | 10.1038/s41467-019-09807-5 |
| Antibody | |
| Antibody: | CR9501 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | espiratory syncytial virus (RSV) F Fusion glycoprotein F0 |
| Antigen mutation: | Yes |
| Durg Target: | P03420; P11209; P03420; P11209; |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6OE5_H|Chain D[auth H]|CR9501 Fab Heavy Chain|Homo sapiens (9606) QVQLVQSGPGLVKPSQTLALTCTVSGASINSDNYYWTWIRQRPGGGLEWIGHISYTGNTYYTPSLKSRLSMSLETSQSQFSLRLTSVTAADSAVYFCAACGAYVLISNCGWFDSWGQGTQVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK |
Light Chain: L
Mutation: NULL
| >6OE5_L|Chain E[auth L]|CR9501 Fab Light Chain|Homo sapiens (9606) EIVMTQSPSSLSASIGDRVTITCQASQDISTYLNWYQQKPGQAPRLLIYGASNLETGVPSRFTGSGYGTDFSVTISSLQPEDIATYYCQQYQYLPYTFAPGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: N67I/S215P
| >6OE5_A|Chain A|Fusion glycoprotein F0,Fibritin|Human respiratory syncytial virus A (strain A2) (11259) MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIELSNIKEIKCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPPTNNRARRELPRFMNYTLNNAKKTNVTLSKKRKRRFLGFLLGVGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEINLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGMDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLSAIGGYIPEAPRDGQAYVRKDGEWVLLSTFLGSLEVLFQG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: VAL2 ASP32 ASN33 TYR34 GLY96 ALA97 TYR98 VAL99 ASP101 L: ASP28 SER30 THR31 TYR32 TYR49 ASN53 LEU54 THR56 TYR67 GLN92 TYR93 A: GLU60 LEU61 SER62 ASN63 ILE64 LYS65 GLU66 ILE67 LYS68 LEU83 ASP84 TYR86 LYS87 VAL90 GLN94 GLU161 GLY162 ASN165 LYS168 SER169 LEU172 LYS196 ASP200 LEU204 ASN208 ILE292 LYS293 GLU294 GLU295 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
