Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2586 |
| PDBID: | 6OCB |
| Chains: | HL_A |
| Organism: | Homo sapiens, Influenza A virus (A/Hong Kong/1/1968(H3N2)) |
| Method: | XRD |
| Resolution (Å): | 2.10 |
| Reference: | 10.1016/j.cell.2019.04.011 |
| Antibody | |
| Antibody: | FluA-20 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H3N2 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | P03437 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6OCB_H|Chain A[auth H]|Heavy chain of FluA-20 Fab|Homo sapiens (9606) QVQLEESGPGLVKPSETLSLTCSVSGVSVTSDIYYWTWIRQPPGKGLEWIGYIFYNGDTNYNPSLKSRVTMSIDTSKNEFSLRLTSVTAADTAVYFCARGTEDLGYCSSGSCPNHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCHHHHHH |
Light Chain: L
Mutation: NULL
| >6OCB_L|Chain B[auth L]|Light chain of FluA-20 Fab|Homo sapiens (9606) DIVMTQSPSSLSASIGDRVTITCRPSQNIRSFLNWFQHKPGKAPKLLIYAASNLQSGVPSRFSGSGSGTEFTLTIRSLQPEDFATYYCQQSYNTPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >6OCB_A|Chain C[auth A]|Hemagglutinin|Influenza A virus (506350) VQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGVHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVGHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: GLN1 ASP32 ILE33 TYR34 ARG94 THR96 GLU97 ASP98 LEU99 ASN101 HIS102 L: ASN28 LEU46 TYR49 ASN53 LEU54 GLN55 SER56 GLY57 SER67 A: SER91 LYS92 SER95 PRO99 TYR100 ASP101 ASN216 ILE217 GLY218 SER219 ARG220 PRO221 TRP222 VAL223 ARG224 GLY225 ARG229 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
