Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2585 |
| PDBID: | 6OC3 |
| Chains: | CD_E |
| Organism: | Homo sapiens, Influenza A virus (A/Solomon Islands/3/2006(H1N1)) |
| Method: | XRD |
| Resolution (Å): | 2.85 |
| Reference: | 10.1016/j.cell.2019.04.011 |
| Antibody | |
| Antibody: | FluA-20 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H1N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >6OC3_C|Chain A, C|Heavy chain of FluA-20 Fab|Homo sapiens (9606) QVQLEESGPGLVKPSETLSLTCSVSGVSVTSDIYYWTWIRQPPGKGLEWIGYIFYNGDTNYNPSLKSRVTMSIDTSKNEFSLRLTSVTAADTAVYFCARGTEDLGYCSSGSCPNHWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCHHHHHH |
Light Chain: D
Mutation: NULL
| >6OC3_D|Chain B, D|Light chain of FluA-20 Fab|Homo sapiens (9606) DIVMTQSPSSLSASIGDRVTITCRPSQNIRSFLNWFQHKPGKAPKLLIYAASNLQSGVPSRFSGSGSGTEFTLTIRSLQPEDFATYYCQQSYNTPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: E
Mutation: NULL
| >6OC3_E|Chain E, F|Hemagglutinin|Influenza A virus (A/Solomon Islands/3/2006(H1N1)) (464623) APLQLGNCSVAGWILGNPECELLISRESWSYIVEKPNPENGTCYPGHFADYEELREQLSSVSSFERFEIFPKESSWPNHTTTGVSASCSHNGESSFYKNLLWLTGKNGLYPNLSKSYANNKEKEVLVLWGVHHPPNIGDQRALYHKENAYVSVVSSHYSRKFTPEIAKRPKVRDQEGRINYYWTLLEPGDTIIFEANGNLIAPRYAFALSRGSGLVPRGSGHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: GLN1 VAL2 VAL27 ASP32 ILE33 TYR34 ARG94 THR96 GLU97 ASP98 LEU99 ASN101 HIS102 D: ARG30 LEU46 TYR49 ASN53 LEU54 GLN55 SER56 SER67 GLY68 E: PRO87 ASN88 THR93 PRO96 GLY97 HIS98 GLU103 GLU216 ILE217 ALA218 LYS219 ARG220 PRO221 LYS222 VAL223 ARG224 ASP225 GLU227 ARG229 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
