Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2576 |
| PDBID: | 6OAN |
| Chains: | B_A |
| Organism: | Plasmodium vivax, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.90 |
| Reference: | 10.1038/s41564-019-0461-2 |
| Antibody | |
| Antibody: | 053054 scFv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Duffy binding surface protein region II |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: B
Mutation: NULL
| >6OAN_B|Chain B, D|Antibody 053054 single chain variable fragment|Homo sapiens (9606) MVHSQVQLQESGPGLVKPSQTLSLTCNVSGDSINSGDYYWIWIRQPPGKGLEWIGNIYYSGTAYYNPSLKTRLIISIDTSTNQFSLKVTSVTAADTAIYYCARASTTVVSPWLDPWGQGTLVTVSSAGGGGSGGGGSGGGGSSVTSYELTQPSSVAVAPGQTARIPCGGDNIESKGVHWYQQKPGQAPVLVVYDDHDRPSGIPERFSGSNSGNTATLTVSRVEAGDEADYYCQVWDTSSEHPVFGGGTKLTVLGQPKAAPSVTLFP |
Antigen
Chain: A
Mutation: NULL
| >6OAN_A|Chain A, C|Duffy binding surface protein region II|Plasmodium vivax (5855) NTVMKNCNYKRKRRERDWDCNTKKDVCIPDRRYQLCMKELTNLVNNTDTNFHRDITFRKLYLKRKLIYDAAVEGDLLLKLNNYRYNKDFCKDIRWSLGDFGDIIMGTDMEGIGYSKVVENNLRSIFGTDEKAQQRRKQWWNESKAQIWTAMMYSVKKRLKGNFIWICKLNVAVNIEPQIYRWIREWGRDYVSELPTEVQKLKEKCDGKINYTDKKVCKVPPCQNACKSYDQWITRKKNQWDVLSNKFISVKNAEKVQTAGIVTPYDILKQELDEFNEVAFENEINKRDGAYIELCVCSVEEAKKNTQEVVTNVDN |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: GLY36 ASP37 TYR39 TYR58 TYR59 SER60 THR62 TYR64 THR106 THR107 VAL108 VAL109 SER110 PRO111 GLU173 SER174 LYS175 GLY176 TYR193 ASP194 ASP195 HIS196 ASP197 TRP235 THR237 SER238 SER239 GLU240 A: GLU249 ASP264 THR266 PHE267 LEU270 TYR271 LYS273 ARG274 LYS275 ILE277 TYR278 ALA281 GLN356 THR359 ALA360 TYR363 LYS366 LYS367 ARG368 LEU369 LYS370 GLY371 ASN372 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
