Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2575 |
| PDBID: | 6O9I |
| Chains: | DE_C |
| Organism: | Homo sapiens, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.60 |
| Reference: | 10.1080/19420862.2019.1710047 |
| Antibody | |
| Antibody: | ECD-Fab2 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Gastric inhibitory polypeptide receptor |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >6O9I_D|Chain D|Fab 2 heavy chain|Homo sapiens (9606) QVQLQQPGAELVKPGASVKLSCRASGYTFTSNWMHWVKQRPRQGLEWIGEINPSNGRSNYNEKFKTKATLTVDKSSSTAYMQLSSLTSEDSAVYYCARFYYGTSWFAYWGQGTLVAVSAAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCGCKPC |
Light Chain: E
Mutation: NULL
| >6O9I_E|Chain E|Fab2 light chain|Homo sapiens (9606) DVVMTQTPLSLPVSLGDQASISCRSSQSLVHSNGDTYLHWYLQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTDFTLKISRVEAADLGVYFCSQSTHVPPFTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: C
Mutation: NULL
| >6O9I_C|Chain C|Gastric inhibitory polypeptide receptor|Mus musculus (10090) MGSSHHHHHHSSGLVPRGSHMETDSEGQTTTGELYQRWEHYGQECQKMLETTEPPSGLACNGSFDMYACWNYTAANTTARVSCPWYLPWFRQVSAGFVFRQCGSDGQWGSWRDHTQCENPEKNGAFQDQTLILERLQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| D: VAL2 GLY26 TYR27 THR28 SER31 ASN32 TRP33 GLU50 ASN52 ASN55 ARG57 ARG98 PHE99 TYR101 GLY102 THR103 SER104 TRP105 E: HIS31 SER32 ASN33 ASP35 TYR37 TYR54 LYS55 ASN58 ARG59 SER61 SER96 THR97 VAL99 PHE102 C: ASP37 TYR39 THR50 PHE71 GLN73 GLN79 TRP80 GLY81 SER82 TRP83 ARG84 ASP85 HIS86 THR87 GLN88 GLU90 LYS94 ASN95 GLU106 ARG107 GLN109 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
