Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2574 |
| PDBID: | 6O9I |
| Chains: | AB_C |
| Organism: | Homo sapiens, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.60 |
| Reference: | 10.1080/19420862.2019.1710047 |
| Antibody | |
| Antibody: | ECD-Fab1 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Gastric inhibitory polypeptide receptor |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >6O9I_A|Chain A|Fab1 heavy chain|Homo sapiens (9606) DVQLVESGGGLVQPGGSRKLSCAASGFTFSSFGMHWVRQAPEKGLEWVAYISSGSSTIYYADTVKGRFTISRDNPKNTLFLQMTSLRSEDTAMYYCARGKYPTWIAYWGQGTLVTVSAAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCGCKPC |
Light Chain: B
Mutation: NULL
| >6O9I_B|Chain B|Fab1 light chain|Homo sapiens (9606) DIVMTQSPSSLTVTAGEKVTMSCKSSQSLLNSGNQKNYLTWYQQKPGQPPKLLISWASTRDSGVPDRFTGSGSGTDFTLTISSVQAEDLAVYYCQNDYSYPLTFGAGTKLELKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: C
Mutation: NULL
| >6O9I_C|Chain C|Gastric inhibitory polypeptide receptor|Mus musculus (10090) MGSSHHHHHHSSGLVPRGSHMETDSEGQTTTGELYQRWEHYGQECQKMLETTEPPSGLACNGSFDMYACWNYTAANTTARVSCPWYLPWFRQVSAGFVFRQCGSDGQWGSWRDHTQCENPEKNGAFQDQTLILERLQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: PHE27 THR28 SER31 PHE32 GLY33 TYR50 SER52 SER53 THR57 TYR59 ARG98 GLY99 LYS100 TYR101 PRO102 THR103 TRP104 B: ASN31 SER32 GLY33 ASN34 GLN35 TYR38 TRP56 ASP97 TYR98 C: ARG9 HIS12 GLN15 GLU16 LYS19 MET20 LEU21 GLU22 THR23 THR24 GLU25 PRO26 TYR44 TRP57 PHE62 ARG63 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
