Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2557 |
| PDBID: | 6NMT |
| Chains: | BA_C |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.83 |
| Reference: | 10.1080/19420862.2019.1624123 |
| Antibody | |
| Antibody: | 3 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Tyrosine-protein phosphatase non-receptor type substrate 1 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >6NMT_B|Chain B|Fab 3 anti-SIRP-alpha antibody Variable Heavy Chain|Homo sapiens (9606) AVTLDESGGGLQTPGGALSLVCKASGFIFSDYGMNWVRQAPGKGLEFVAQITSGSRTYYGAAVKGRATISRDNRQSTVKLQLNNLRAEDTGIYFCARDFGSGVGSIDAWGNGTEVIVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCHHHHHH |
Light Chain: A
Mutation: NULL
| >6NMT_A|Chain A|Fab 3 anti-SIRP-alpha antibody Variable Light Chain|Homo sapiens (9606) ALTQPASVSANLGGTVKITCSGSRGRYGWYQQRSPGSAPVTVIYRDNQRPSNIPSRFSSSTSGSTSTLTITGVQADDESVYFCGSYDGSIDIFGAGTTLTVLRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: C
Mutation: NULL
| >6NMT_C|Chain C|Tyrosine-protein phosphatase non-receptor type substrate 1|Homo sapiens (9606) EEELQVIQPDKSVLVAAGETATLRCTATSLIPVGPIQWFRGAGPGRELIYNQKEGHFPRVTTVSDLTKRNNMDFSIRIGAITPADAGTYYCVKFRKGSPDDVEFKSGAGTELSVRAKPSTRHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: ARG24 GLY25 ARG26 ARG45 TYR86 ASP87 GLY88 SER89 B: ASP31 GLN50 THR52 SER53 GLY54 ARG56 TYR58 PHE99 GLY100 SER101 GLY102 C: VAL6 ILE7 GLN8 PRO9 ASP10 LYS11 SER12 LEU14 ARG24 THR26 THR28 MET72 THR88 TYR90 ALA108 GLY109 GLU111 ARG115 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
