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Entry information

Complex
AACDB_ID: 2540
PDBID: 6NFC
Chains: HL_A
Organism: Macaca mulatta, Human immunodeficiency virus 1, Homo sapiens
Method: EM
Resolution (Å): 3.43
Reference: 10.1126/science.aax4380
Antibody
Antibody: BG18-like Fv
Antibody mutation: No
INN (Clinical Trial):
Antigen
Antigen: HIV-1 BG505 MD64 N332-GT5 SOSIP gp120
Antigen mutation: No
Durg Target:

Sequence information

Antibody

Heavy Chain: H
Mutation: NULL

>6NFC_H|Chain E[auth H]|BG18-like precursor HMP42 fragment antigen binding heavy chain|Homo sapiens (9606)
QVQLVQSGAEVKKPGASVKVSCKASGYTFTGYYMHWVRQAPGQGLEWMGWINPNSGGTNYAQKFQGRVTMTRDTSISTAYMELSRLRSDDTAVYYCARDRGREWELESYYYYYYMDVWGKGTTVTVSS

Light Chain: L
Mutation: NULL

>6NFC_L|Chain F[auth L]|BG18-like precursor HMP42 fragment antigen binding light chain|Homo sapiens (9606)
SYELTQPPSVSVSPGQTARITCSGDALPKQYAYWYQQKPGQAPVLVIYKDSERPSGIPERFSGSSSGTTVTLTISGVQAEDEADYYCQSADSSGTYVVFGGGTKLTVL

Antigen

Chain: A
Mutation: NULL

>6NFC_A|Chain C[auth A], I[auth E], K[auth F]|HIV-1 Env BG505 MD64 N332-GT5 SOSIP gp120|Human immunodeficiency virus 1 (11676)
AENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHEDIISLWDQSLKPCVKLTPLCVTLQCTNYAPKLRSMMRGEIKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVIIRSENITNNAKNILVQLNTPVQINCTRPSNNTVKSIRIGPGQAFYYFGDVLGHVRMAHCNISKATWNETLGKVVKQLRKHFGNNTIIRFAQSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSLILPCWIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVGRRRRRR

Interaction

1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.

Interacting residues (ΔSASA based)

L: LEU28 PRO29 LYS30 GLN31 TYR32 LYS50 ASP51 SER66 GLY68 VAL71 ALA91

A: PRO136 LYS137 LEU138 ARG139 SER140 MET141 ARG151 HIS325 ARG327 MET328 HIS330 ILE415 PRO417

2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.

Interacting residues (Atom distance based)

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