Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2539 |
| PDBID: | 6NF5 |
| Chains: | EF_C |
| Organism: | Human immunodeficiency virus 1, Homo sapiens, Macaca mulatta |
| Method: | EM |
| Resolution (Å): | 3.71 |
| Reference: | 10.1126/science.aax4380 |
| Antibody | |
| Antibody: | BG18-like Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | HIV-1 BG505 MD64 N332-GT5 SOSIP gp120 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: E
Mutation: NULL
| >6NF5_E|Chain C[auth E], I[auth H], O|BG18-like precursor HMP1 fragment antigen binding heavy chain|Homo sapiens (9606) QVQLQESGPGLVKPSQTLSLTCTVSGGSISSGSYYWSWIRQPAGKGLEWIGRIYTSGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCAREGFTIFGVVTFSEGYYYGMDVWGKGTTVTVSS |
Light Chain: F
Mutation: NULL
| >6NF5_F|Chain D[auth F], J[auth L], P|BG18-like precursor HMP1 fragment antigen binding light chain|Homo sapiens (9606) SYELTQPPSVSVSPGQTARITCSGDALPKQYAYWYQQKPGQAPVLVIYKDSERPSGIPERFSGSSSGTTVTLTISGVQAEDEADYYCQSADSSGEVFGGGTKLTVL |
Antigen
Chain: C
Mutation: NULL
| >6NF5_C|Chain A, G[auth C], M[auth J]|HIV-1 Env BG505 MD64 N332-GT5 SOSIP gp120|Human immunodeficiency virus 1 (11676) AENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWATHACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHEDIISLWDQSLKPCVKLTPLCVTLQCTNYAPKLRSMMRGEIKNCSFNMTTELRDKKQKVYSLFYRLDVVQINENQGNRSNNSNKEYRLINCNTSAITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVIIRSENITNNAKNILVQLNTPVQINCTRPSNNTVKSIRIGPGQAFYYFGDVLGHVRMAHCNISKATWNETLGKVVKQLRKHFGNNTIIRFAQSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNTSVQGSNSTGSNDSLILPCWIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKRRVVGRRRRRR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| F: LEU28 PRO29 LYS30 GLN31 TYR32 ASP51 SER66 C: PRO136 LYS137 ARG139 SER140 MET141 ARG151 HIS325 VAL326 ARG327 MET328 HIS330 ILE415 PRO417 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
