Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2524 |
| PDBID: | 6N6B |
| Chains: | KL_A |
| Organism: | Influenza A virus (A/Minnesota/11/2010(H3N2)), Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.30 |
| Reference: | 10.1038/s41564-019-0522-6 |
| Antibody | |
| Antibody: | B10 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | H3N2 neuraminidase |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: K
Mutation: NULL
| >6N6B_K|Chain B[auth K]|B10 antibody Heavy Chain Fab|Mus musculus (10090) DVQLEQSGPGLVKPSQSLSLTCTVTGYSITTDYAWNWIRQFPGNKLEWMGYISYTGSTTYNPSLKSRISITRDTSKNQFFLQLISVNAEDTATYYCARRGDYDYFDYWGQGTTLTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGPT |
Light Chain: L
Mutation: NULL
| >6N6B_L|Chain C[auth L]|B10 antibody Light Chain Fab|Mus musculus (10090) DVVMTQSHKFMSTSVGDRVSITCRASQDVGPSVAWYQQKPGQSPRLLIYWASTRHTGVPDRFTGSGSETDFTLTIANVESEDLADYFCQQYSSYPLTFGAGTKLDLRRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: A
Mutation: NULL
| >6N6B_A|Chain A|Neuraminidase|Influenza A virus (A/Minnesota/11/2010(H3N2)) (1507381) GSGDSGSPGAEYRNWSKPQCNITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDPDKCYQFALGQGTTLNNRHSNNTVHDRSPYRTLLMNELGVPFHLGTRQVCIAWSSSSCHDGKAWLHVCITGDDNNATASFIYNGRLVDSIGSWSKNILRTQESECVCINGTCTVVMTDGSASGKADTKILFIEEGKIVHISTLSGSAQHVEECSCYPRYPGVRCVCRDNWKGSNRPIVDINMKDYSIASSYVCSGLVGDTPRKNDSFSSSHCLDPNNEKGGHGVKGWAFDDGNDVWMGRTISEEFRLGYETFKVIKGWSNPNSKLQTNRQVIVEKGNRSGYSGVFSIEDKSCINRCFYVELIRGRKEETKVWWTSNSIVVFCGTSGTYGTGSWPDGADINLMPI |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| K: TYR27 SER28 THR30 THR31 ASP32 TYR33 TYR51 SER53 TYR54 THR55 SER57 THR58 THR59 ARG99 ASP101 TYR102 ASP103 L: ASP28 VAL29 GLY30 PRO31 SER32 TRP50 SER52 THR53 SER67 GLU68 TYR91 SER92 SER93 TYR94 A: ASN147 VAL149 HIS150 ASP151 ARG152 SER153 ASP197 ASP198 ASN199 ASN221 SER245 ALA246 SER247 GLY248 LYS249 GLN273 ARG292 ASN294 TRP295 LYS296 ASN342 LYS344 GLY345 GLY346 HIS347 GLU369 LYS431 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
