Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2518 |
| PDBID: | 6N5D |
| Chains: | CD_A |
| Organism: | Influenza A virus, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 3.00 |
| Reference: | 10.1016/j.chom.2019.04.003 |
| Antibody | |
| Antibody: | FL-1066 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | P03437 |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >6N5D_C|Chain B[auth C], D[auth E], F[auth L]|antibody heavy chain|Mus musculus (10090) ASDVKLVESGEGLVKPGGSLKLSCAASGFTFSSYDMSWVRQTPEKRLEWVAYISSGGDYIYYADTVKGRFTISRDNARNTLYLQMSSLKSEDTAMYYCTRVGEYDAWFAYWDQGTLVTVSGASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKGSSLEVLFQ |
Light Chain: D
Mutation: NULL
| >6N5D_D|Chain G[auth D], H[auth F], I[auth N]|antibody light chain|Mus musculus (10090) ASQAVVTQESALTTSPGETVTLTCRSSTGAVTTSNYANWVQEKPDHLFAGLIGGTKNRAPGVPARFSGSLIGDKAALTITGAQTEDEAIYFCALWYSNHWVFGGGTKLTVLGQPKGAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >6N5D_A|Chain A, C[auth B], E[auth K]|Hemagglutinin|Influenza A virus (11320) TNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWLTKSGSTYPVLNVTMPNNDNFDKLYIWGIHHPSTDQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLAT |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: PHE27 THR28 SER30 SER31 TYR32 ASP33 TRP47 TYR50 SER52 SER53 ASP56 TYR57 TYR59 GLU101 TYR102 TRP105 D: SER32 TYR34 TRP93 SER95 ASN96 TRP98 A: SER91 LYS92 ALA93 PHE94 SER95 ASN96 PRO99 SER136 ASN137 ALA138 SER219 ARG220 PRO221 TRP222 VAL223 ARG224 GLY225 LEU226 ARG229 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
