Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2517 |
| PDBID: | 6N5B |
| Chains: | HL_B |
| Organism: | Mus musculus, Influenza A virus |
| Method: | XRD |
| Resolution (Å): | 3.50 |
| Reference: | 10.1016/j.chom.2019.04.003 |
| Antibody | |
| Antibody: | 8H10 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6N5B_H|Chain A[auth H]|antibody heavy chain|Mus musculus (10090) EVQLQESGEGLVKPGGSLKLSCAASGFTFSNYDMSWVRQTPEKRLEWVAYISSGGDYIYYADTVKGRFTISRDNARNTLYLQMSSLKSEDTAMYYCTRNYYYGSLPVWFAYWGQGTLVTVSGAAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVP |
Light Chain: L
Mutation: NULL
| >6N5B_L|Chain B[auth L]|antibody light chain|Mus musculus (10090) QAVVTQESALTTSPGETVTLTCRSSTGAVTTSNYANWVQEKPDHLFTGLIGGTNNRAPGVPARFSGSLIGDKAALTITGAQTEDEAIYFCALWYSNHSWVFGGGTKLTVLGQPKGAPSVTLFPPSSEELETNKATLVCTITDFYPGVVTVDWKVDGTPVTQGMETTQPSKQSNNKYMASSYLTLTARAWERHSSYSCQVTHEGHTVEKSLS |
Antigen
Chain: B
Mutation: NULL
| >6N5B_B|Chain C[auth B]|Hemagglutinin|Influenza A virus (11320) PLRLVDGQTCDIVNGALGSPGCDHLNGAEWDIFIERPTAVDTCYPFDVPDYQSLRSILANNGKFEFIAEEFQWSTVTQNGGSNACKRANVNDFFNRLNWLTKSGSTYPLQNLTKINNGDYARLYIWGVHHPSTDQEQTNLYKNNPGRVTVSTKTSQTSVVPNIGSRPWVRGLSSRISFYWTIVEPGDLIVFNTIGNLIAPRGHYKLNSQKKSTILNTAVPI |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ASN31 TYR32 ASP33 TRP47 TYR50 SER52 ASP55 TYR56 TYR58 TYR96 TYR97 TYR98 GLY99 SER100 LEU101 PRO102 TRP104 L: TYR34 TRP93 SER95 HIS97 SER98 TRP99 B: ASP61 GLU85 ARG86 PRO87 ALA89 VAL90 ASP91 THR92 ASP97 TYR101 GLN102 ASN133 SER215 ARG216 PRO217 TRP218 VAL219 ARG220 GLY221 LEU222 ARG225 ASN266 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
