Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2516 |
| PDBID: | 6N48 |
| Chains: | B_A |
| Organism: | Enterobacteria phage RB59, Homo sapiens, Camelidae |
| Method: | XRD |
| Resolution (Å): | 3.20 |
| Reference: | 10.1126/science.aaw8981 |
| Antibody | |
| Antibody: | 6B9 Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Beta-2 adrenergic receptor chimera |
| Antigen mutation: | No |
| Durg Target: | P00720 |
Sequence information
Antibody
Chain: B
Mutation: NULL
| >6N48_B|Chain B|Camelid Antibody Fragment|Camelidae (9835) QVQLQESGGGLVQAGGSLRLSCAASGSIFALNIMGWYRQAPGKQRELVAAIHSGGTTNYANSVKGRFTISRDNAANTVYLQMNSLKPEDTAVYYCNVKDFGAIIYDYDYWGQGTQVTVSS |
Antigen
Chain: A
Mutation: NULL
| >6N48_A|Chain A|Endolysin,Beta-2 adrenergic receptor,Beta-2 adrenergic receptor chimera|Enterobacteria phage RB59 (697290) DYKDDDDAENLYFQGNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTKSPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRTGTWDAYAADEVWVVGMGIVMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAAHILTKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQEAINCYAEETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKFALKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQDNLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: SER27 ILE28 PHE29 ALA30 LEU31 ILE33 LEU47 ALA50 HIS52 SER53 GLY54 GLY55 THR56 THR57 ASN58 ARG71 ASP72 ASN73 ALA74 ASN76 ASP99 PHE100 GLY101 ALA102 ILE103 ILE104 TYR105 ASP106 TYR107 TYR109 A: THR1068 ILE1072 ILE1127 ARG1131 ALA1134 ILE1135 THR1136 SER1137 PRO1138 PHE1139 LYS1140 GLN1142 TYR1219 VAL1222 GLU1225 ALA1226 GLN1229 LEU1230 GLN1231 ALA1265 LEU1266 LYS1267 GLU1268 ALA1271 THR1274 LEU1275 ILE1278 ILE1325 TYR1326 ARG1328 SER1329 PRO1330 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
