Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2463 |
| PDBID: | 6MEK |
| Chains: | IG_A |
| Organism: | Hepacivirus hominis, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.10 |
| Reference: | 10.1016/j.chom.2018.10.009 |
| Antibody | |
| Antibody: | HEPC46 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Hepatitis C virus envelope glycoprotein E2 |
| Antigen mutation: | No |
| Durg Target: | P26664; P26664; |
Sequence information
Antibody
Heavy Chain: I
Mutation: NULL
| >6MEK_I|Chain F, I|HEPC46 Heavy Chain|Homo sapiens (9606) QVQLVQSGAEVKKPGASVKVSCKASGYIFTSHGISWVRQAPGQGLEWMGWISVYNGYTNYAQNLQGRVTMTTDTSTSTAYMELRSLRSDDTAVYFCARASQIRGVDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHHHHHH |
Light Chain: G
Mutation: NULL
| >6MEK_G|Chain E, G|HEPC46 Light Chain|Homo sapiens (9606) QSVLTQPPSASGTPGQRVTISCSGSSSNIGSNYVYWYQQFPGTAPKLLIYGNNQRPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCAAWDDSLSGPWVFGGGTQVTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >6MEK_A|Chain A, C|E2 GLYCOPROTEIN|Hepacivirus C (3052230) NQLINTNGSWHLNRTALNCNDSLNTGWLAGLFYHHKFDSSGCPERMASCRPLTDFDQGWGPISHANGSGPDGSSGCWHYPPRPCGIVPAKTVCGPVYCFTPSPVVVGTTDRAGAPAYNWGENDTDVFVLNNTRPPLGNWFGCTWMNSTGFTKACGAPPCAIGGVGDKTLYCPTDCFRKHPEATYSRCGSGPWITPRCLVDYPYRLWHYPCTINYTVFKIRMYVGGVEHRLEAACN |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| G: SER30 ASN31 TYR32 TRP91 ASP93 I: ILE28 THR30 SER31 HIS32 GLY33 TRP50 ILE51 TYR53 ASN54 TYR56 ALA95 SER96 GLN97 ILE98 A: ILE496 THR510 VAL514 VAL516 ARG521 VAL538 ASN540 THR542 ARG543 PRO544 PRO545 LEU546 GLY547 ASN548 TRP549 PRO567 CYS569 SER595 ARG596 GLY634 VAL636 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
