Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2462 |
| PDBID: | 6MEK |
| Chains: | HL_C |
| Organism: | Hepacivirus hominis, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.10 |
| Reference: | 10.1016/j.chom.2018.10.009 |
| Antibody | |
| Antibody: | HEPC3 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Hepatitis C virus envelope glycoprotein E2 |
| Antigen mutation: | No |
| Durg Target: | P26664; P26664; |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6MEK_H|Chain B, H|HEPC3 Heavy Chain|Homo sapiens (9606) QVQLVQSGAEVKKPGSSVKVSCKASGGTLNSYEITWVRQAPGQGLEWMGGITPIFETTYAQKFQGRVTITADESTSTTYMELSSLRPEDTAVYYCARDGVRYCGGGRCYNWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTAGWSHPQFEK |
Light Chain: L
Mutation: NULL
| >6MEK_L|Chain D, J[auth L]|HEPC3 Light Chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCRAGQNINNYLNWYQQKPGKAPKVLIYAASNLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSHSTVRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: C
Mutation: NULL
| >6MEK_C|Chain A, C|E2 GLYCOPROTEIN|Hepacivirus C (3052230) NQLINTNGSWHLNRTALNCNDSLNTGWLAGLFYHHKFDSSGCPERMASCRPLTDFDQGWGPISHANGSGPDGSSGCWHYPPRPCGIVPAKTVCGPVYCFTPSPVVVGTTDRAGAPAYNWGENDTDVFVLNNTRPPLGNWFGCTWMNSTGFTKACGAPPCAIGGVGDKTLYCPTDCFRKHPEATYSRCGSGPWITPRCLVDYPYRLWHYPCTINYTVFKIRMYVGGVEHRLEAACN |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: GLN1 VAL2 GLY27 THR28 LEU29 ASN30 SER31 TYR32 GLU33 THR52 PRO53 ILE54 PHE55 GLU73 SER76 ARG94 VAL97 ARG98 TYR99 ASP101 PRO102 L: TYR49 SER56 C: LEU427 ASN428 CYS429 ASN430 ASP431 SER432 LEU433 ASN434 THR435 GLY436 TRP437 LEU438 ALA439 GLY440 PHE442 TYR443 HIS444 HIS445 LYS446 PHE447 ASP448 TRP529 GLU531 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
