Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2458 |
| PDBID: | 6MEI |
| Chains: | HL_C |
| Organism: | Hepacivirus hominis, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.90 |
| Reference: | 10.1016/j.chom.2018.10.009 |
| Antibody | |
| Antibody: | HEPC3 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Hepatitis C virus envelope glycoprotein E2 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6MEI_H|Chain B[auth H]|antibody HEPC3 Heavy Chain|Homo sapiens (9606) QVQLVQSGAEVKKPGSSVKVSCKASGGTLNSYEITWVRQAPGQGLEWMGGITPIFETTYAQKFQGRVTITADESTSTTYMELSSLRPEDTAVYYCARDGVRYCGGGRCYNWFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTAGWSHPQFEK |
Light Chain: L
Mutation: NULL
| >6MEI_L|Chain C[auth L]|antibody HEPC3 Light Chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCRAGQNINNYLNWYQQKPGKAPKVLIYAASNLQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSHSTVRTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: C
Mutation: NULL
| >6MEI_C|Chain A[auth C]|E2 glycoprotein|Hepacivirus C (3052230) STHVTGGTASHTTRHFASLFSSGASQRVQLINTNGSWHINRTALNCNDSLHTGFLAALFYTHKFNASGCPERMAHCRPIDEFAQGWGPITYAEGHGSDQRPYCWHYAPRQCGTIPASQVCGPVYCFTPSPVVVGTTDRFGAPTYTWGENETDVLILNNTRPPQGNWFGCTWMNSTGFTKTCGGPPCNIGGVGNNTLTCPTDCFRKHPEATYTKCGSGPWLTPRCLVDYPYRLWHYPCTVNFTIFKVRMYVGGVEHRLNAACNIGHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: GLN1 GLY27 THR28 LEU29 ASN30 SER31 GLU33 THR52 PRO53 ILE54 PHE55 GLU56 GLU73 ARG94 GLY96 VAL97 ARG98 TYR99 ASP101 PRO102 L: TYR32 TYR49 GLN55 SER56 C: ILE414 ASN417 GLY418 SER419 TRP420 LEU427 ASN428 CYS429 ASN430 ASP431 SER432 HIS434 THR435 GLY436 LEU438 ALA439 ALA440 PHE442 TYR443 HIS445 LYS446 PHE447 ASN448 ALA449 TRP529 GLU531 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
