Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2457 |
| PDBID: | 6MEH |
| Chains: | HL_C |
| Organism: | Hepacivirus hominis, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.99 |
| Reference: | 10.1016/j.chom.2018.10.009 |
| Antibody | |
| Antibody: | HEPC74 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Hepatitis C virus envelope glycoprotein E2 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6MEH_H|Chain B[auth H]|antibody HEPC74 Heavy Chain|Homo sapiens (9606) QVQLVQSGAEVKKPGSSVKVSCTTSGGTYINYAISWVRQAPGQGLEWVGGMSPISNTPKYAQKFQGRVTITADESTSTTYMELSSLRPEDTAVYYCARDLLKYCGGGNCHSLLVDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHHHHHH |
Light Chain: L
Mutation: NULL
| >6MEH_L|Chain C[auth L]|antibody HEPC74 Light Chain|Homo sapiens (9606) DIVMTQSPSTLSASVGDRVTISCRASQSISSWLAWYQQKPGRAPKLLIYKASSLETGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCQHYNTYLFTFGPGTKVDLKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: C
Mutation: NULL
| >6MEH_C|Chain A[auth C]|E2 glycoprotein|Hepacivirus C (3052230) STHVTGGTASHTTRHFASLFSSGASQRVQLINTNGSWHINRTALNCNDSLHTGFLAALFYTHKFNASGCPERMAHCRPIDEFAQGWGPITYAEGHGSDQRPYCWHYAPRQCGTIPASQVCGPVYCFTPSPVVVGTTDRFGAPTYTWGENETDVLILNNTRPPQGNWFGCTWMNSTGFTKTCGGPPCNIGGVGNNTLTCPTDCFRKHPEATYTKCGSGPWLTPRCLVDYPYRLWHYPCTVNFTIFKVRMYVGGVEHRLNAACN |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: GLY26 GLY27 THR28 TYR29 ILE30 ASN31 TYR32 ALA33 PRO52 ILE53 SER54 ASN55 ARG94 LEU96 LEU97 LYS98 TYR99 VAL100 ASP101 L: TYR49 GLU55 THR56 C: HIS421 LEU427 CYS429 ASN430 ASP431 SER432 LEU433 HIS434 THR435 GLY436 PHE437 LEU438 ALA439 ALA440 PHE442 TYR443 HIS445 LYS446 PHE447 ASN448 TRP529 GLU531 TRP616 PRO619 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
