Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2449 |
| PDBID: | 6M3C |
| Chains: | JK_G |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.70 |
| Reference: | 10.1038/s41467-020-16720-9 |
| Antibody | |
| Antibody: | h1573 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Vitamin K-dependent protein C heavy chain |
| Antigen mutation: | No |
| Durg Target: | P04070 |
Sequence information
Antibody
Heavy Chain: J
Mutation: NULL
| >6M3C_J|Chain C[auth E], G[auth J], K[auth L]|h1573 Fab H chain|Homo sapiens (9606) DIVLTQSPASLAVSPGQRATITCKASESVDSFGATFMHWYQQKPGQPPKLLIYLASNLESGVPARFSGSGSGTDFTLTINPVEADDTANYYCQQNNEDPYTFGQGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Light Chain: K
Mutation: NULL
| >6M3C_K|Chain D[auth F], H, L[auth K]|h1573 Fab L chain|Homo sapiens (9606) EVQLVESGGGLVQPGGSLRLSCAASGFTFSNYYLNWVRQAPGKGLEWVGDIRLKSNNYEKHYAESVKGRFTISRDDSKNSLYLQMNSLKTEDTAVYYCAREGDYFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Antigen
Chain: G
Mutation: NULL
| >6M3C_G|Chain A, E[auth C], I[auth G]|Vitamin K-dependent protein C heavy chain|Homo sapiens (9606) LIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| J: ASP30 SER31 PHE32 GLY33 ALA34 PHE36 TYR53 LEU54 SER56 ASN57 ASN95 ASN96 GLU97 ASP98 TYR100 K: ASN31 TYR32 TYR33 ARG52 LEU53 GLU59 HIS61 GLU101 GLY102 ASP103 TYR104 G: TYR344 SER346 SER347 ARG348 GLU349 LYS350 GLU351 ALA352 VAL376 SER378 GLY392 ARG394 CYS398 GLU399 GLY423 GLU424 GLY425 CYS426 LEU428 LEU429 HIS430 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
