Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2447 |
| PDBID: | 6M3B |
| Chains: | CB_A |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.20 |
| Reference: | 10.1038/s41467-020-16720-9 |
| Antibody | |
| Antibody: | c25k23 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Vitamin K-dependent protein C heavy chain |
| Antigen mutation: | No |
| Durg Target: | P04070 |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >6M3B_C|Chain D[auth C]|c25k23 Fab H chain|Homo sapiens (9606) EVQLLESGGGLVQPGGSLRLSCAASGFTFSSYWMSWVRQAPGKGLEWVSGVSWNGSRTHYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCALTGRSGWMRFPNWFDPWGQGTLVTVTSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVE |
Light Chain: B
Mutation: NULL
| >6M3B_B|Chain C[auth B]|c25k23 Fab L chain|Homo sapiens (9606) SVLTQPPSASGTPGQRVTISCTGSSSNIGAAYDVHWYQQLPGTAPKLLIYGNNKRPSGVPDRFSGSKSGTSASLAISGLRSEDEADYYCQSYDSSLSGSVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTE |
Antigen
Chain: A
Mutation: NULL
| >6M3B_A|Chain A|Vitamin K-dependent protein C heavy chain|Homo sapiens (9606) LIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: TYR51 LYS55 ARG56 PRO57 SER58 C: SER30 SER31 TYR32 TRP33 SER52 TRP53 ASN54 ARG57 LEU98 GLY100 ARG101 SER102 GLY103 TRP104 MET105 ARG106 PHE107 PRO108 TRP110 ASP112 A: HIS57 GLU60 SER95 LYS96 SER97 THR98 THR99 SER169 GLU170 VAL171 MET172 SER173 ASN174 MET175 ASP189 ALA190 CYS191 GLU192 SER195 VAL213 SER214 TRP215 GLY216 GLU217 GLY218 CYS219 LEU221 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
