Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2429 |
| PDBID: | 6LXI |
| Chains: | HL_A |
| Organism: | Influenza A virus (A/Brevig Mission/1/1918(H1N1)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.50 |
| Reference: | 10.1128/mBio.02315-20 |
| Antibody | |
| Antibody: | Z2B3 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | H1N1 neuraminidase |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6LXI_H|Chain B[auth C], E[auth H]|Heavy chain of Z2B3 Fab|Homo sapiens (9606) EVQLVQSGAEVKKPGSSVKVSCKASGGPFSSYGFSWVRQAPGQGLEWMGGIIPVYGTTNYAQKFQGRVTITADESTSTAYMELSSLKSEDTAVYYCARDLQDTPMVDRIIGSYYYYNGLDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDK |
Light Chain: L
Mutation: NULL
| >6LXI_L|Chain C[auth D], F[auth L]|Light chain of Z2B3 Fab|Homo sapiens (9606) QSVLTQPASVSGSPGQSITISCTGASSDVGDYNYVSWYQQHPGKAPKLMIYDVSNRPSGVSNRFSGSKSGDTASLTISGLQAEDEADYYCSSYTRSSSVVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: A
Mutation: NULL
| >6LXI_A|Chain A, D[auth B]|Neuraminidase|Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (88776) MNPNQKIITIGSICMVVGIISLILQIGNIISIWVSHSIQTGNQNHPETCNQSIITYENNTWVNQTYVNISNTNVVAGQDATSVILTGNSSLCPISGWAIYSKDNGIRIGSKGDVFVIREPFISCSHLECRTFFLTQGALLNDKHSNGTVKDRSPYRTLMSCPVGEAPSPYNSRFESVAWSASACHDGMGWLTIGISGPDNGAVAVLKYNGIITDTIKSWRNNILRTQESECACVNGSCFTIMTDGPSNGQASYKILKIEKGKVTKSIELNAPNYHYEECSCYPDTGKVMCVCRDNWHGSNRPWVSFDQNLDYQIGYICSGVFGDNPRPNDGTGSCGPVSSNGANGIKGFSFRYDNGVWIGRTKSTSSRSGFEMIWDPNGWTETDSSFSVRQDIVAITDWSGYSGSFVQHPELTGLDCMRPCFWVELIRGQPKENTIWTSGSSISFCGVNSDTVGWSWPDGAELPFSIDK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: SER30 SER31 VAL54 TYR55 GLY56 GLU74 ASP102 THR103 PRO104 MET105 VAL106 ASP107 ARG108 ILE109 ILE110 TYR113 L: ASP31 TYR32 TYR34 ARG95 SER97 A: ARG118 GLU119 VAL149 LYS150 ASP151 ARG152 TRP179 SER180 ASN222 ILE223 ARG225 GLU228 SER247 ASN248 GLU277 GLU278 ARG293 TRP296 PRO326 ALA343 ASN344 GLY345 SER367 ARG368 TYR402 GLN430 PRO431 LYS432 ILE436 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
