Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2427 |
| PDBID: | 6LN2 |
| Chains: | CB_A |
| Organism: | Homo sapiens, Clostridium pasteurianum, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 3.20 |
| Reference: | 10.1038/s41467-020-14934-5 |
| Antibody | |
| Antibody: | 7F38 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Glucagon-like peptide 1 receptor |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >6LN2_C|Chain C|Fab7F38_heavy chain|Mus musculus (10090) EVQLQQSGPELVKPGASVKMSCKAPGYTFTSYVTHWVKQKPGQGLEWIGYINPYNDSPKYNEKYKAKATLTSDKSSSTVYMELSSLTSEDSAVYYCARIGYFRYDEGGNYALDYWGQGTSVTVSSASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESK |
Light Chain: B
Mutation: NULL
| >6LN2_B|Chain B|Fab7F38_light chain|Mus musculus (10090) QIVLTQSPAIMSASPGEKVTISCSASSSVSYMYWYQQKPGSSPKPWIYRTSKLASGVPVRFSGSGSGTSYSLTISNMEAEDAATYYCQQFHTYPWTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >6LN2_A|Chain A|Glucagon-like peptide 1 receptor,Rubredoxin,Glucagon-like peptide 1 receptor|Homo sapiens (9606) RPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALCVFFKDAALKWMYSTAAQQHQWDGLLSYQDSLACRLVFLLCQYCVAANYYWLLVEGVYLYTLLAFSVLMKKYTCTVCGYIYNPEDGDPDNGVNPGTDFKDIPDDWVCPLCGVGKDQFEEVEEEQWIFRLYVAIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFACIVNFLIFVRVICIVVSKLKANLMCKTDIAFRLAKSTLTLIPLLCTHEVIFAFVMDEHARGTLRFIKLFTDLSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCP |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: SER30 PHE90 HIS91 THR92 TYR93 TRP95 C: PHE29 THR30 SER31 TYR32 VAL33 HIS35 TYR50 ASN52 TYR54 ASN55 ILE99 TYR101 ARG103 TYR104 ASP105 GLU106 GLY107 GLY108 ASN109 TYR110 A: ALA57 THR58 ASP59 LEU60 GLU76 PRO77 GLY78 SER79 PHE80 PHE103 THR105 ALA106 GLU107 LEU109 LEU111 GLN112 LYS113 ASP114 ASN115 SER116 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
