Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2425 |
| PDBID: | 6LGW |
| Chains: | C_F |
| Organism: | Mus musculus, Lyssavirus rabies |
| Method: | XRD |
| Resolution (Å): | 2.90 |
| Reference: | 10.1016/j.chom.2019.12.012 |
| Antibody | |
| Antibody: | 523-11 scFv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Rabies virus glycoprotein |
| Antigen mutation: | No |
| Durg Target: | P08667 |
Sequence information
Antibody
Chain: C
Mutation: NULL
| >6LGW_C|Chain A, C|scFv 523-11|Mus musculus (10090) EVQLQQFGAELVKPGASVKISCKASGYTFTDYNMDWVKQSHGKSLQWIGDISPYYGSTGYSQKFKGKATLTVDRSSSTAYMELRSLTSEDTAVYYCARRNYDGSWFAYWGQGTLVTVSSMELVMTQSPAILSVSPGERVSFSCRASQIIGTSIHWYQQRTNGSPRLLIKYASESISGIPSRFSGSGSGTDFTLTINSVESDDIADYYCQQSNSWPVTFGAGTKLELKR |
Antigen
Chain: F
Mutation: NULL
| >6LGW_F|Chain B[auth E], D[auth F]|Glycoprotein|Lyssavirus rabies (11292) ADEFKFPIYTIPDELGPWSPIDIHHLSCPNNLVVEDEGCTNLSEFSYMELKVGYISAIKVNGFTCTGVVTEAETYTGGSGGTTFKRKHFRPTPDACRAAYNWKMAGDPRYEESLHNPYGGSGGRTTKESLIIISPSVTDLDPYDKSLHSRVFPGGKCSGITVSSTYCSTNHDYTIWMPENPRPRTPCDIFTNSRGKRASNGNKTCGFVDERGLYKSLKGACRLKLCGVLGLRLMDGTWVAMQTSDETKWCPPDQLVNLHDFRSDEIEHLVVEELVKKREECLDALESIMTTKSVSFRRLSHLRKLVPGFGKAYTIFNKTLMEADAHYKSVRTWNEIIPSKGCLKVGGRCHPHVNGVFFNGIILGPDDHVLIPEMQSSLLQQHMELLKSSVIPLMHPLADPSTVHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: THR30 ASP31 TYR32 ASN33 ASP50 ILE51 SER52 PRO53 TYR54 TYR55 GLY56 SER57 THR58 GLY59 TYR60 THR71 VAL72 ARG74 SER75 ASN100 TYR101 ASP102 GLY103 SER104 TYR170 SER211 ASN212 SER213 TRP214 F: LYS330 ARG333 THR334 TRP335 ASN336 GLU337 ILE339 PRO340 SER341 LYS342 LYS346 GLY349 ARG350 CYS351 ASP368 HIS370 VAL371 LEU372 MET376 GLN377 LEU380 GLN383 HIS384 LEU387 LEU388 SER390 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
