Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2421 |
| PDBID: | 6L62 |
| Chains: | HL_A |
| Organism: | Mus musculus, Porcine circovirus 2 |
| Method: | EM |
| Resolution (Å): | 7.20 |
| Reference: | 10.1128/JVI.01836-19 |
| Antibody | |
| Antibody: | MAb 3A5 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | porcine circovirus type 2 capsid protein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >6L62_H|Chain B[auth H]|Heavy chain of Fab fragment|Mus musculus (10090) QVQLQQSGAELVRPGVSVKISCKGSGYTFTDYAIHWVKQSHAKSLEWIGLISTYYGDATYNQNFKGEATMTVDKSSSTAYMELARLTSEDSAIYYCARGPFSRYDYFAMDNWGQGTSVTVSSAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIV |
Light Chain: L
Mutation: NULL
| >6L62_L|Chain A[auth L]|Light chain of Fab fragment|Mus musculus (10090) NIVMTQSPKSMSMSVGERVTLSCKASENVGTFVFWYQQKPEQSPQLLIYGASNRYTGVPDRFTGSGSATDFTLTINNVQAEDFVDYYCGQSYRYPLTFAAGTKLGLKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRN |
Antigen
Chain: A
Mutation: NULL
| >6L62_A|Chain C[auth A]|Capsid protein|Porcine circovirus 2 (85708) MTYPRRRFRRRRHRPRSHLGLILRRRPWLVHPRHRYRWRRKNGIFNTRLSCTFGYTVKATTVRTPSWAVDMMRFNINDFVPPGGGTNKISIPFEYYRIRKVKVEFWPCSPITQGDRGVGSTAVILDDNFVTKATALTYDPYVNYSSRHTIPQPFSYHSRYFTPKPVLDSTIDYFQPNNKRNQLWLRLQTSANVDHVGLGIAFENSTYDQDYNIRVTMYVQFREFNLKDPPL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition L: THR31 PHE32 TYR49 GLY50 SER52 ASN53 H: THR242 ASP243 TYR244 TYR266 PHE313 SER314 ARG315 TYR316 ASP317 TYR318 A: TYR55 THR56 VAL57 LYS58 THR60 THR61 VAL62 THR64 ALA68 VAL69 ASP70 MET71 ASP127 ASN128 PHE129 THR131 LYS132 ALA133 THR134 ALA135 LEU136 THR137 ASN204 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
