Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2417 |
| PDBID: | 6KZ0 |
| Chains: | BC_A |
| Organism: | rhinovirus B14, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.40 |
| Reference: | 10.1073/pnas.1918844117 |
| Antibody | |
| Antibody: | GGVV Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | rhinovirus B14 genome polyprotein |
| Antigen mutation: | No |
| Durg Target: | P03303 |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >6KZ0_B|Chain B, E, H, K|GGVV H chain|Homo sapiens (9606) GAMMAQVQLVQSGAEVKQPGSSVKVSCKTSGDIFSTYGFNWVRQAPGQGLEWMGGIAPVFDTLKYAQRFQGRLLITADESATSVYMELSSLRSDDTAVYYCARAGQGGVVGNYLDYWGQGTLVTVSSGGGGSGGGGSGGGGS |
Light Chain: C
Mutation: NULL
| >6KZ0_C|Chain C, F, I, L|GGVV L chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCRASQGISNYLAWYQQKPGKVPKLLIYAASTLQSGVPSRFSGSGSGTDFTLTISSLQPEDVATYYCQKYNSAPLTFGQGTKVDIKR |
Antigen
Chain: A
Mutation: NULL
| >6KZ0_A|Chain A, D, G, J|Genome polyprotein|Human rhinovirus 14 (12131) GSGPNTEFALSLLRKNIMTITTSKGEFTGLGIHDRVCVIPTHAQPGDDVLVNGQKIRVKDKYKLVDPENINLELTVLTLDRNEKFRDIRGFISEDLEGVDATLVVHSNNFTNTILEVGPVTMAGLINLSSTPTNRMIRYDYATKTGQCGGVLCATGKIFGIHVGGNGRQGFSAQLKKQYFVEKQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition B: SER32 THR33 PRO55 VAL56 PHE57 ASP58 THR59 LYS61 GLN103 GLY104 GLY105 VAL106 VAL107 GLY108 ASN109 C: TYR32 TYR91 ASN92 SER93 A: SER0 GLY1 PRO2 ASN3 GLU5 PHE6 SER9 LEU10 ARG12 LYS13 ASN14 ARG84 ASP85 ILE86 GLY88 PHE89 THR153 GLY154 LYS155 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
