Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2415 |
| PDBID: | 6KYZ |
| Chains: | BC_A |
| Organism: | rhinovirus B14, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.84 |
| Reference: | 10.1073/pnas.1918844117 |
| Antibody | |
| Antibody: | YDF Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | rhinovirus B14 genome polyprotein |
| Antigen mutation: | No |
| Durg Target: | P03303 |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >6KYZ_B|Chain B, E|YDF H chain|Homo sapiens (9606) SNMAQVQLLQSGGGVVQPGRSLRLSCAASGFTFSSYAMHWVRQAPGKGLEWVAVISYDGSNKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARVGKGGYDFWSGSGYMDVWGKGTTVTVSSGGGGSGGGGSGGGGS |
Light Chain: C
Mutation: NULL
| >6KYZ_C|Chain C, F|YDF L chain|Homo sapiens (9606) SYVLTQPPSVSVSPGQTASITCSGDKLGDKYACWYQQKPGQSPVLVIYQDSKRPSGIPERFSGSNSGNTATLTISGTQAMDEADYYCQAWDSSTVVFGGGTKLTVLG |
Antigen
Chain: A
Mutation: NULL
| >6KYZ_A|Chain A, D|Genome polyprotein|Human rhinovirus 14 (12131) GSGPNTEFALSLLRKNIMTITTSKGEFTGLGIHDRVCVIPTHAQPGDDVLVNGQKIRVKDKYKLVDPENINLELTVLTLDRNEKFRDIRGFISEDLEGVDATLVVHSNNFTNTILEVGPVTMAGLINLSSTPTNRMIRYDYATKTGQCGGVLCATGKIFGIHVGGNGRQGFSAQLKKQYFVEKQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition B: THR30 SER33 TYR34 TYR55 LYS103 GLY104 GLY105 TYR106 ASP107 PHE108 TRP109 C: GLY28 ASP29 LYS30 TYR31 TYR48 GLN49 ASP50 SER51 LYS52 SER64 ASN65 TRP90 ASP91 SER92 A: PRO2 THR4 LEU8 LEU11 ASN107 PHE108 THR109 ASN110 THR111 ILE112 LEU113 GLU114 ASP138 TYR139 ALA140 LYS142 THR143 GLY144 GLN145 GLY165 ARG166 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
