Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2414 |
| PDBID: | 6KTR |
| Chains: | FG_D |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.60 |
| Reference: | 10.1111/cas.14353 |
| Antibody | |
| Antibody: | G1A8 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Fibroblast growth factor 19 |
| Antigen mutation: | No |
| Durg Target: | O95750 |
Sequence information
Antibody
Heavy Chain: F
Mutation: NULL
| >6KTR_F|Chain A, E[auth F]|G1A8-Fab-HC|Homo sapiens (9606) EVQLLETGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDNWQELLFDYWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKAEPKSCDKTHTHHHHHH |
Light Chain: G
Mutation: NULL
| >6KTR_G|Chain B, F[auth G]|G1A8-Fab-LC|Homo sapiens (9606) QAGLTQPASVSGSPGQSITISCTGTSSDVGGYNYVSWYQQHPGKAPKLMIYDVSNRPSGVSDRFSGSKSGNTASLTISGLQTEDEADYYCSSWTRSSGLVFGGGTQLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADGSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: D
Mutation: NULL
| >6KTR_D|Chain C, D|Fibroblast growth factor 19|Homo sapiens (9606) RPLAFSDAGPHVHYGWGDPIRLRHLYTSGPHGLSSCFLRIRADGVVDCARGQSAHSLLEIKAVALRTVAIKGVHSVRYLCMGADGKMQGLLQYSEEDCAFEEEIRPDGYNVYRSEKHRLPVSLSSAKQRQLYKNRGFLPLSHFLPMLPMVPEEPEDLRGHLESDMFSSPLETDSMDPFGLVTGLEAVRSPSFEKSGGGHHHHHHLNDIFEAQKIEWHE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition F: GLU1 VAL2 PHE27 TYR32 ALA33 ALA50 ILE51 SER52 SER57 THR58 TYR59 LYS98 ASN100 TRP101 GLN102 GLU103 LEU104 LEU105 ASP107 TYR108 G: TYR32 ASN33 TYR34 LEU48 TYR51 ASP52 SER54 ASN55 ARG56 PRO57 SER58 TRP93 ARG95 D: GLY37 TRP38 GLY39 ASP40 PRO41 ILE42 ARG43 LEU44 ARG45 GLU81 VAL95 GLU124 ILE126 GLY130 LEU166 PRO167 MET168 LEU169 PRO170 MET171 VAL172 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
