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Entry information

Complex
AACDB_ID: 2409
PDBID: 6KRZ
Chains: FG_B
Organism: Homo sapiens, Mus musculus
Method: XRD
Resolution (Å): 3.05
Reference: 10.1038/s42003-020-01160-4
Antibody
Antibody: A208 Fv
Antibody mutation: No
INN (Clinical Trial):
Antigen
Antigen: human adiponectin receptor 1
Antigen mutation: Yes
Durg Target:

Sequence information

Antibody

Heavy Chain: F
Mutation: NULL

>6KRZ_F|Chain D, F, H|The heavy chain variable domain (Antibody)|Mus musculus (10090)
EVLLQQSGPELVKPGASVRITCKASGYTFTDFNMDWVKQSPGKSLEWIGDFNPNSGGSIYNQKFKDKATFTVDKSSSTAYMELRSLTFEDTAVYYCARETGTAWFAYWGQGTLVTVSAA

Light Chain: G
Mutation: NULL

>6KRZ_G|Chain E, G, I|The light chain variable domain (Antibody)|Mus musculus (10090)
DIQMTQSPASLSASVGETVTITCRASGNIHNFLAWYQQKQGKSPQVLVYNAKTLADGVPSRFSGSGSGTQYSLKINSLQPEDFGSYYCQQFWSTPYTFGGGTKLEIN

Antigen

Chain: B
Mutation: D138A

>6KRZ_B|Chain A, B, C|Adiponectin receptor protein 1|Homo sapiens (9606)
MDYKDDDDKENLYFQGGSEGRWRVIPYDVLPDWLKDNDYLLHGHRPPMPSFRACFKSIFRIHTETGNIWTHLLGFVLFLFLGILTMLRPNMYFMAPLQEKVVFGMFFLGAVLCLSFSWLFHTVYCHSEKVSRTFSKLAYSGIALLIMGSFVPWLYYSFYCSPQPRLIYLSIVCVLGISAIIVAQWDRFATPKHRQTRAGVFLGLGLSGVVPTMHFTIAEGFVKATTVGQMGWFFLMAVMYITGAGLYAARIPERFFPGKFDIWFQSHQIFHVLVVAAAFVHFYGVSNLQEFRYGLEGGCTDDTLL

Interaction

1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.

Interacting residues (ΔSASA based)

Chain residues position delta_SASA : residuesposition

F: THR30 ASP31 PHE32 ASN33 ASP50 ASN52 ASN54 ILE59 ARG98 THR100 GLY101 THR102 TRP104

G: HIS30 ASN31 PHE32 TYR49 ASN50 LYS52 THR53 PHE91 TRP92 SER93 THR94 TYR96

B: SER0 GLU89 GLY90 ARG91 TRP92 ARG93 VAL94 ILE95 PRO96 VAL99 PRO101 TRP103 HIS112 PRO116 PRO117 MET118 PRO119 SER120 ARG122 ALA123 SER197 GLU198 LYS199

2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.

Interacting residues (Atom distance based)

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