Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2404 |
| PDBID: | 6KN9 |
| Chains: | D_A |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.30 |
| Reference: | 10.1016/j.jmb.2020.01.012 |
| Antibody | |
| Antibody: | 6KN9 scFv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Interleukin-18 receptor accessory protein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: D
Mutation: NULL
| >6KN9_D|Chain D, E, F|scFv|Homo sapiens (9606) GPLDPEVQLVESGGGLVQPGGSLRLSCAASGFNLYYSSMHWVRQAPGKGLEWVASIYSSYGYTYYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARSSFSHGYGWYGLDYWGQGTLVTVSSSSGGGGSGGGGSGGGGSDIQMTQSPSSLSASVGDRVTITCRASQSVSSAVAWYQQKPGKAPKLLIYSASSLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQYGYHYAGLITFGQGTKVEIKRT |
Antigen
Chain: A
Mutation: NULL
| >6KN9_A|Chain A, B, C|Interleukin-18 receptor accessory protein|Homo sapiens (9606) FNISGCSTKKLLWTYSTRSEEEFVLFCDLPEPQKSHFCHRNRLSPKQVPEHLPFMGSNDLSDVQWYQQPSNGDPLEDIRKSYPHIIQDKCTLHFLTPGVNNSGSYICRPKMIKSPYDVACCVKMILEVKPQTNASCEYSASHKQDLLLGSTGSISCPSLSCQSDAQSPAVTWYKNGKLLSVERSNRIVVDEVYDYHQGTYVCDYTQSDTVSSWTVRAVVQVRTIVGDTKLKPDILDPVEDTLEVELGKPLTISCKARFGFERVFNPVIKWYIKDSDLEWEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQLKEKR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition D: PRO-3 ASP-1 PRO0 GLU1 VAL2 GLY26 PHE27 ASN28 TYR30 TYR31 ARG98 SER100 SER102 HIS103 GLY104 TYR105 GLY106 TRP107 TYR108 ASP111 TYR112 THR160 ALA172 TYR189 SER190 ALA191 SER192 SER193 LEU194 TYR195 PHE202 SER205 ARG206 SER207 GLY208 A: ILE105 ASP107 HIS112 LEU167 ASP213 GLN216 GLY217 THR218 VAL240 ARG241 THR242 ILE243 VAL244 ASP246 GLY278 PHE279 GLU280 ARG281 VAL282 PHE283 ASN284 PRO285 GLU304 LYS306 SER307 SER310 THR311 LEU312 GLU315 ILE317 SER342 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
