Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2400 |
| PDBID: | 6K7O |
| Chains: | DE_Q |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.00 |
| Reference: | 10.1158/2326-6066.CIR-19-0036 |
| Antibody | |
| Antibody: | h128-3 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >6K7O_D|Chain B, D, F, H|h128-3 Fab heavy chain|Homo sapiens (9606) EVQLLESGGGLVQPGGSLRLSCAASGIDFSNHYYMYWVRQAPGKGLEWIGSIFSGDSASTYYADSAKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARGMSTNDWASDLWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKT |
Light Chain: E
Mutation: NULL
| >6K7O_E|Chain C, E, G, I[auth L]|h128-3 Fab light chain|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCQASESINSIYLAWYQQKPGKAPKLLIYRASTLASGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSYDWGDVENTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: Q
Mutation: NULL
| >6K7O_Q|Chain A, J[auth P], K[auth Q], L[auth R]|Leukocyte immunoglobulin-like receptor subfamily B member 4|Homo sapiens (9606) GPLPKPTLWAEPGSVISWGNSVTIWCQGTLEAREYRLDKEESPAPWDRQNPLEPKNKARFSIPSMTEDYAGRYRCYYRSPVGWSQPSDPLELVMT |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| D: HIS32 TYR34 PHE53 GLY55 SER57 SER59 TYR61 SER103 THR104 ASP106 TRP107 E: GLU27 ASN30 ILE32 TYR33 SER92 TYR93 ASP94 TRP95 GLY96 Q: LEU30 GLU31 ALA32 ARG33 GLU34 ASN50 PRO51 GLU53 PRO54 LYS55 ARG78 SER79 PRO80 VAL81 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
