Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 24 |
| PDBID: | 1DVF |
| Chains: | BA_C |
| Organism: | Mus musculus |
| Method: | XRD |
| Resolution (Å): | 1.90 |
| Reference: | 10.1006/jmbi.1996.0629 |
| Antibody | |
| Antibody: | anti-idiotype E5.2 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | D1.3 Fv light chain |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >1DVF_B|Chain B|FV D1.3|Mus musculus (10090) QVQLQESGPGLVAPSQSLSITCTVSGFSLTGYGVNWVRQPPGKGLEWLGMIWGDGNTDYNSALKSRLSISKDNSKSQVFLKMNSLHTDDTARYYCARERDYRLDYWGQGTTLTVSS |
Light Chain: A
Mutation: NULL
| >1DVF_A|Chain A|FV D1.3|Mus musculus (10090) DIVLTQSPASLSASVGETVTITCRASGNIHNYLAWYQQKQGKSPQLLVYYTTTLADGVPSRFSGSGSGTQYSLKINSLQPEDFGSYYCQHFWSTPRTFGGGTKLEIKR |
Antigen
Chain: C
Mutation: NULL
| >1DVF_C|Chain C|FV E5.2|Mus musculus (10090) DIQLTQSPSSLSASLGDRVTISCRASQDISNYLNWYQQKPDGTVKLLIYYTSRLHSGVPSRFSGSGSGTDYSLTISNLEQEDIATYFCQQGNTLPWTFGGGTKLEIK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: HIS30 TYR32 TYR50 TRP92 SER93 THR94 B: ASP54 ASN56 ASP58 C: TYR32 TYR49 TYR50 ARG53 ASN92 THR93 LEU94 TRP96 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
