Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2398 |
| PDBID: | 6K6B |
| Chains: | A_B |
| Organism: | Homo sapiens, Staphylococcus aureus |
| Method: | XRD |
| Resolution (Å): | 2.06 |
| Reference: | 10.1073/pnas.1910080116 |
| Antibody | |
| Antibody: | Anti-huntingtin VL-intrabody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Protein A #8496 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: A
Mutation: NULL
| >6K6B_A|Chain A|3LRH intrabody|Homo sapiens (9606) MGSSHHHHHHSSGLVPRGSHMGSQPVLTQSPSVSAAPRQRVTISVSGSNSNIGSNTVNWIQQLPGRAPELLMYDDDLLAPGVSDRFSGSRSGTSASLTISGLQSEDEADYYAATWDDSLNGWVFGGGTKVTVLSA |
Antigen
Chain: B
Mutation: NULL
| >6K6B_B|Chain B|Protein A|Staphylococcus aureus (1280) MGSSHHHHHHSSGLVPRGSHMEKLMKAFQSLAFFEILNMPNLNEAQRNGFIQSLKDDPSQSTNVLGEAKKLNESQAP |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: THR36 ASN38 ILE40 GLN42 ALA47 PRO48 GLU49 LEU50 TYR53 ASP54 ALA59 PRO60 TYR91 ALA93 TRP95 ASN100 GLY101 TRP102 PHE104 B: LYS3 LEU4 LYS6 ALA7 PHE8 GLN9 SER10 LEU11 PHE13 PHE14 GLU15 LEU17 ASN18 LYS35 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
