Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2396 |
| PDBID: | 6K6A |
| Chains: | B_C |
| Organism: | Homo sapiens, Staphylococcus aureus |
| Method: | XRD |
| Resolution (Å): | 1.94 |
| Reference: | 10.1073/pnas.1910080116 |
| Antibody | |
| Antibody: | Anti-huntingtin VL-intrabody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Protein A #8188cys |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: B
Mutation: NULL
| >6K6A_B|Chain A, B|3LRH intrabody|Homo sapiens (9606) MGSSHHHHHHSSGLVPRGSHMGSQPVLTQSPSVSAAPRQRVTISVSGSNSNIGSNTVNWIQQLPGRAPELLMCDDDLLAPGVSDRFSGSRSGTSASLTISGLQSEDEADYYAATWDDSLNGWVFGGGTKVTVLSA |
Antigen
Chain: C
Mutation: NULL
| >6K6A_C|Chain C, D|Engineered Protein A|Staphylococcus aureus (1280) MGSSHHHHHHSSGLVPRGSHMFNKDQQSAFYEILNMPNLNEAQRNGFIQSLKDDPSQSTNVLGEAKKLNKCQASLKSFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: ASN35 ILE37 GLN39 ALA44 PRO45 GLU46 LEU47 CYS50 ASP51 LEU54 ALA56 PRO57 TYR88 ALA90 TRP92 TRP99 PHE101 C: ASN1821 GLN1824 PHE1828 GLU1845 LYS1848 LEU1849 LYS1851 CYS1852 GLN1853 ALA1854 SER1855 LEU1856 SER1858 PHE1859 GLN1860 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
