Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 2391 |
| PDBID: | 6K68 |
| Chains: | AB_H |
| Organism: | Mus musculus, Staphylococcus aureus |
| Method: | XRD |
| Resolution (Å): | 3.20 |
| Reference: | 10.1073/pnas.1910080116 |
| Antibody | |
| Antibody: | 13H11 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Protein A #8420 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >6K68_A|Chain A, C, F, J|3MNZ Variable heavy chain|Mus musculus (10090) DPQIQLVQSGPELKKPGETVKISCKASGYTFTDYSVHWVKQVPGKGLKWMGWINTETGEPTYADDFKGRFAFSLESSASTAYLEIHNLTNEDTATYFCALGWLHWGLGTTLTVSS |
Light Chain: B
Mutation: NULL
| >6K68_B|Chain B, D, G, K|3MNZ Variable light chain|Mus musculus (10090) DIQLTQSPSSLAMSGGQKVTMRCKSSQSLLNSRNERNYLAWYQQKPGQSPKLLVYFASIRESGVPDRFIGSGSGTDFTLTISSVQAEDLADYFCLQHYNTPWTFGGGTKLEIKSGR |
Antigen
Chain: H
Mutation: NULL
| >6K68_H|Chain E, H, I, L|Protein A|Staphylococcus aureus (1280) MGSSHHHHHHSSGLVPRGSHMFNKDQQSAFYEILNMPNLNEAQRNGFIQSLKDDPSQSTNVLLEADKWASLQN |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| A: ILE4 TYR29 THR30 THR32 ASP33 TYR34 SER35 TRP52 ASN54 THR55 GLU56 LEU100 GLY101 TRP102 LEU103 B: ARG163 ASN164 ARG166 TYR168 TYR185 PHE186 ILE189 GLU191 HIS227 H: GLU13 ASN21 GLN24 THR40 LEU43 LEU44 GLU45 ASP47 LYS48 TRP49 ALA50 SER51 LEU52 GLN53 ASN54 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
